Enhancement and suppression in a lexical interference fMRI-paradigm

被引:21
作者
Abel, Stefanie [1 ,2 ,3 ]
Dressel, Katharina [2 ,3 ]
Weiller, Cornelius [3 ]
Huber, Walter [2 ]
机构
[1] Rhein Westfal TH Aachen, Fac Med, Sect Neuropsychol, Aachen, Germany
[2] Rhein Westfal TH Aachen, Fac Med, Sect Clin Res Cognit, Aachen, Germany
[3] Univ Med Ctr Freiburg, Dept Neurol, Freiburg, Germany
来源
BRAIN AND BEHAVIOR | 2012年 / 2卷 / 02期
关键词
Facilitation; fMRI; inhibition; naming; picture-word interference task; semantic priming; visual object priming; word processing;
D O I
10.1002/brb3.31
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Previous picture-word interference (PWI) fMRI-paradigms revealed ambiguous mechanisms underlying facilitation and inhibition in healthy subjects. Lexical distractors revealed increased (enhancement) or decreased (suppression) activation in language and monitoring/control areas. Performing a secondary examination and data analysis, we aimed to illuminate the relation between behavioral and neural interference effects comparing target-related distractors (REL) with unrelated distractors (UNREL). We hypothesized that interference involves both (A) suppression due to priming and (B) enhancement due to simultaneous distractor and target processing. Comparisons to UNREL should remain distractor unspecific even at a low threshold. (C) Distractor types with common characteristics should reveal overlapping brain areas. In a 3T MRI scanner, participants were asked to name pictures while auditory words were presented (stimulus onset asynchrony [SOA] = -200 msec). Associatively and phonologically related distractors speeded responses (facilitation), while categorically related distractors slowed them down (inhibition) compared to UNREL. As a result, (A) reduced brain activations indeed resembled previously reported patterns of neural priming. Each target-related distractor yielded suppressions at least in areas associated with vision and conflict/competition monitoring (anterior cingulate cortex [ACC]), revealing least priming for inhibitors. (B) Enhancements concerned language-related but distractor-unspecific regions. (C) Some wider brain regions were commonly suppressed for combinations of distractor types. Overlapping areas associated with conceptual priming were found for facilitatory distractors (inferior frontal gyri), and areas related to phonetic/articulatory processing (precentral gyri and left parietal operculum/insula) for distractors sharing feature overlap. Each distractor with semantic relatedness revealed nonoverlapping suppressions in lexical-phonological areas (superior temporal regions). To conclude, interference combines suppression of areas well known from neural priming and enhancement of language-related areas caused by dual activation from target and distractor. Differences between interference and priming need to be taken into account. The present interference paradigm has the potential to reveal the functioning of word-processing stages, cognitive control, and responsiveness to priming at the same time.
引用
收藏
页码:109 / 127
页数:19
相关论文
共 78 条
  • [1] The Influence of Handedness on Hemispheric Interaction During Word Production: Insights from Effective Connectivity Analysis
    Abel, Stefanie
    Huber, Walter
    Weiller, Cornelius
    Amunts, Katrin
    Eickhoff, Simon B.
    Heim, Stefan
    [J]. BRAIN CONNECTIVITY, 2011, 1 (03) : 219 - 231
  • [2] Correct and erroneous picture naming responses in healthy subjects
    Abel, Stefanie
    Dressel, Katharina
    Kuemmerer, Dorothee
    Saur, Dorothee
    Mader, Irina
    Weiller, Cornelius
    Huber, Walter
    [J]. NEUROSCIENCE LETTERS, 2009, 463 (03) : 167 - 171
  • [3] The separation of processing stages in a lexical interference fMRI-paradigm
    Abel, Stefanie
    Dressel, Katharina
    Bitzer, Ruth
    Kuemmerer, Dorothee
    Mader, Irina
    Weiller, Cornelius
    Huber, Walter
    [J]. NEUROIMAGE, 2009, 44 (03) : 1113 - 1124
  • [4] The role of the supplementary motor area (SMA) in word production
    Alario, FX
    Chainay, H
    Lehericy, S
    Cohen, L
    [J]. BRAIN RESEARCH, 2006, 1076 : 129 - 143
  • [5] Semantic and associative priming in picture naming
    Alario, FX
    Segui, J
    Ferrand, L
    [J]. QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION A-HUMAN EXPERIMENTAL PSYCHOLOGY, 2000, 53 (03): : 741 - 764
  • [6] Meeting of minds: the medial frontal cortex and social cognition
    Amodio, DM
    Frith, CD
    [J]. NATURE REVIEWS NEUROSCIENCE, 2006, 7 (04) : 268 - 277
  • [7] [Anonymous], 2001, CELEX GERM DAT
  • [8] Selection, integration, and conflict monitoring: Assessing the nature and generality of prefrontal cognitive control mechanisms
    Badre, D
    Wagner, AD
    [J]. NEURON, 2004, 41 (03) : 473 - 487
  • [9] Neural correlates of auditory repetition priming: Reduced fMRI activation in the auditory cortex
    Bergerbest, D
    Ghahremani, DG
    Gabrieli, JDE
    [J]. JOURNAL OF COGNITIVE NEUROSCIENCE, 2004, 16 (06) : 966 - 977
  • [10] Functional MRI of language: New approaches to understanding the cortical organization of semantic processing
    Bookheimer, S
    [J]. ANNUAL REVIEW OF NEUROSCIENCE, 2002, 25 : 151 - 188