Good's syndrome (GS) is often accompanied by recurrent respiratory infections and chronic diarrhea. The main purpose was to evaluate the peripheral immune status of a GS patient after thymoma resection. Twenty healthy volunteers were recruited as healthy controls (HCs). Flow cytometry was applied to determine the proportions of circuiting CD4(+) T cells, CD8(+) T cells, gamma delta T cells, and regulatory T (Treg) cells in our GS patient. We also examined the proliferation capability of ex vivo CD4(+) T cells and detected the levels of cytokines interferon- (IFN-) gamma and interleukin-17A secreted by ex vivo immune cells from this GS patient. Compared with healthy control subjects, this GS patient had fewer B cells, an inverted ratio of CD4(+)/CD8(+) cells, and more Treg cells in his peripheral blood. Additionally, the patient's V delta 2 T cell levels were significantly decreased despite having a normal percentage of gamma delta T cells. Ex vivo peripheral CD4(+) T cells from the patient showed insufficient proliferation and division potential as well as excessive expression of PD-1. Moreover, IFN-gamma was predominantly derived from CD8(+) T cells in this GS patient, rather than from CD4(+) T cells and gamma delta T cells. This GS patient had impaired T and B cell immunological alternations and cytokine disruptions after thymectomy. Detailed research should focus on therapies that can adjust the immune status in such patients for a better outcome.
机构:
ACECR, Avicenna Res Inst, Monoclonal Antibody Res Ctr, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
Jeddi-Tehrani, Mahmood
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Abolhassani, Hassan
Sadeghi, Bamdad
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Res Ctr Immunodeficiencies, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
Sadeghi, Bamdad
Mirminachi, Babak
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h-index: 0
机构:
Univ Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Res Ctr Immunodeficiencies, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
Mirminachi, Babak
Shaghaghi, Mohammadreza
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h-index: 0
机构:
Univ Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Res Ctr Immunodeficiencies, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
Shaghaghi, Mohammadreza
Aghamohammadi, Asghar
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h-index: 0
机构:
Univ Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Res Ctr Immunodeficiencies, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
机构:
St James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, England
Arumugakani, Gururaj
Wood, Philip M. D.
论文数: 0引用数: 0
h-index: 0
机构:
St James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, England
St James Univ Hosp, Cellular Immunol Lab, Dept Immunol & Transplant Immunol, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, England
Wood, Philip M. D.
Carter, Clive R. D.
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h-index: 0
机构:
St James Univ Hosp, Cellular Immunol Lab, Dept Immunol & Transplant Immunol, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, England
机构:
Mazandaran Univ Med Sci, Sch Med, Dept Immunol, Sari, IranUniv Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
Hafezi, Nasim
Mohammadi, Hamed
论文数: 0引用数: 0
h-index: 0
机构:
Tabriz Univ Med Sci, Sch Med, Dept Immunol, Tabriz, IranUniv Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
Mohammadi, Hamed
Yazdai, Reza
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
Isfahan Univ Med Sci, Fac Med, Dept Immunol, Esfahan, IranUniv Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
Yazdai, Reza
Alinia, Tina
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h-index: 0
机构:
Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, IranUniv Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
Alinia, Tina
Tavakol, Marzieh
论文数: 0引用数: 0
h-index: 0
机构:
Alborz Univ Med Sci, Shahid Bahonar Hosp, Dept Allergy & Clin Immunol, Karaj, IranUniv Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
Tavakol, Marzieh
Aghamohammadi, Asghar
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
USERN, PIDNet, Tehran, IranUniv Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
机构:
Childrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA
Campbell, D. E.
Tustin, N. B.
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h-index: 0
机构:
Childrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA
Tustin, N. B.
Riedel, E.
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h-index: 0
机构:
Childrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA
Riedel, E.
Tustin, R., III
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA
Tustin, R., III
Taylor, J.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA
Taylor, J.
Murray, J.
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h-index: 0
机构:
Childrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA
Murray, J.
Douglas, S. D.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA
机构:
St James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, England
Carter, Clive R. D.
Aravind, Ganesha
论文数: 0引用数: 0
h-index: 0
机构:
St James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, England
Aravind, Ganesha
Smalle, Natuley L.
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h-index: 0
机构:
St James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, England
Smalle, Natuley L.
Cole, June Y.
论文数: 0引用数: 0
h-index: 0
机构:
St James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, England
Cole, June Y.
Savic, Sinisa
论文数: 0引用数: 0
h-index: 0
机构:
St James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, England
Savic, Sinisa
Wood, Philip M. D.
论文数: 0引用数: 0
h-index: 0
机构:
St James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, England
St James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, England
机构:
ACECR, Avicenna Res Inst, Monoclonal Antibody Res Ctr, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
Jeddi-Tehrani, Mahmood
论文数: 引用数:
h-index:
机构:
Abolhassani, Hassan
Sadeghi, Bamdad
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Res Ctr Immunodeficiencies, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
Sadeghi, Bamdad
Mirminachi, Babak
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Res Ctr Immunodeficiencies, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
Mirminachi, Babak
Shaghaghi, Mohammadreza
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Res Ctr Immunodeficiencies, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
Shaghaghi, Mohammadreza
Aghamohammadi, Asghar
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Res Ctr Immunodeficiencies, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
机构:
St James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, England
Arumugakani, Gururaj
Wood, Philip M. D.
论文数: 0引用数: 0
h-index: 0
机构:
St James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, England
St James Univ Hosp, Cellular Immunol Lab, Dept Immunol & Transplant Immunol, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, England
Wood, Philip M. D.
Carter, Clive R. D.
论文数: 0引用数: 0
h-index: 0
机构:
St James Univ Hosp, Cellular Immunol Lab, Dept Immunol & Transplant Immunol, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, England
机构:
Mazandaran Univ Med Sci, Sch Med, Dept Immunol, Sari, IranUniv Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
Hafezi, Nasim
Mohammadi, Hamed
论文数: 0引用数: 0
h-index: 0
机构:
Tabriz Univ Med Sci, Sch Med, Dept Immunol, Tabriz, IranUniv Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
Mohammadi, Hamed
Yazdai, Reza
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
Isfahan Univ Med Sci, Fac Med, Dept Immunol, Esfahan, IranUniv Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
Yazdai, Reza
Alinia, Tina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, IranUniv Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
Alinia, Tina
Tavakol, Marzieh
论文数: 0引用数: 0
h-index: 0
机构:
Alborz Univ Med Sci, Shahid Bahonar Hosp, Dept Allergy & Clin Immunol, Karaj, IranUniv Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
Tavakol, Marzieh
Aghamohammadi, Asghar
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
USERN, PIDNet, Tehran, IranUniv Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran
机构:
Childrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA
Campbell, D. E.
Tustin, N. B.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA
Tustin, N. B.
Riedel, E.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA
Riedel, E.
Tustin, R., III
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA
Tustin, R., III
Taylor, J.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA
Taylor, J.
Murray, J.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA
Murray, J.
Douglas, S. D.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Allergy & Immunol, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA
机构:
St James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, England
Carter, Clive R. D.
Aravind, Ganesha
论文数: 0引用数: 0
h-index: 0
机构:
St James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, England
Aravind, Ganesha
Smalle, Natuley L.
论文数: 0引用数: 0
h-index: 0
机构:
St James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, England
Smalle, Natuley L.
Cole, June Y.
论文数: 0引用数: 0
h-index: 0
机构:
St James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, England
Cole, June Y.
Savic, Sinisa
论文数: 0引用数: 0
h-index: 0
机构:
St James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, England
Savic, Sinisa
Wood, Philip M. D.
论文数: 0引用数: 0
h-index: 0
机构:
St James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, England
St James Univ Hosp, Dept Clin Immunol, Leeds LS9 7TF, W Yorkshire, EnglandSt James Univ Hosp, Dept Immunol & Transplant Immunol, Cellular Immunol Lab, Leeds LS9 7TF, W Yorkshire, England