Exploring Pluripotency with Chemical Genetics

被引:13
作者
Doble, Bradley W. [2 ]
Woodgett, James R. [1 ,3 ]
机构
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
[2] McMaster Univ, McMaster Stem Cell & Canc Res Inst, Hamilton, ON L8N 3Z5, Canada
[3] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1X5, Canada
关键词
EMBRYONIC STEM-CELLS; SELF-RENEWAL; ACTIVATION; FATE;
D O I
10.1016/j.stem.2009.01.005
中图分类号
Q813 [细胞工程];
学科分类号
摘要
引用
收藏
页码:98 / 100
页数:3
相关论文
共 10 条
[1]   Generation of multipotential mesendodermal progenitors from mouse embryonic stem cells via sustained Wnt pathway activation [J].
Bakre, Manjiri Manohar ;
Hoi, Aina ;
Mong, Jamie Chen Yee ;
Koh, Yvonne Yiling ;
Wong, Kee Yew ;
Stanton, Lawrence W. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (43) :31703-31712
[2]   Involvement of GSK-3 in Regulation of Murine Embryonic Stem Cell Self-Renewal Revealed by a Series of Bisindolylmaleimides [J].
Bone, Heather K. ;
Damiano, Teresa ;
Bartlett, Stephen ;
Perry, Alexis ;
Letchford, Julie ;
Ripoll, Yolanda Sanchez ;
Nelson, Adam S. ;
Welham, Melanie J. .
CHEMISTRY & BIOLOGY, 2009, 16 (01) :15-27
[3]   Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells [J].
Cole, Megan F. ;
Johnstone, Sarah E. ;
Newman, Jamie J. ;
Kagey, Michael H. ;
Young, Richard A. .
GENES & DEVELOPMENT, 2008, 22 (06) :746-755
[4]  
Ding S, 2003, P NATL ACAD SCI USA, V100, P7632, DOI 10.1073/pnas.0732087100
[5]   Functional redundancy of GSK-3α and GSK-3β in Wnt/β-catenin signaling shown by using an allelic series of embryonic stem cell lines [J].
Doble, Bradley W. ;
Patel, Satish ;
Wood, Geoffrey A. ;
Kockeritz, Lisa K. ;
Woodgett, James R. .
DEVELOPMENTAL CELL, 2007, 12 (06) :957-971
[6]   Defining the role of Wnt/β-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells [J].
Dravid, G ;
Ye, ZH ;
Hammond, H ;
Chen, GB ;
Pyle, A ;
Donovan, P ;
Yu, XB ;
Cheng, LZ .
STEM CELLS, 2005, 23 (10) :1489-1501
[7]   Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor [J].
Sato, N ;
Meijer, L ;
Skaltsounis, L ;
Greengard, P ;
Brivanlou, AH .
NATURE MEDICINE, 2004, 10 (01) :55-63
[8]   Phosphoinositide 3-kinases and regulation of embryonic stem cell fate [J].
Welham, M. J. ;
Storm, M. P. ;
Kingham, E. ;
Bone, H. K. .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2007, 35 :225-228
[9]   The ground state of embryonic stem cell self-renewal [J].
Ying, Qi-Long ;
Wray, Jason ;
Nichols, Jennifer ;
Batlle-Morera, Laura ;
Doble, Bradley ;
Woodgett, James ;
Cohen, Philip ;
Smith, Austin .
NATURE, 2008, 453 (7194) :519-U5
[10]   BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3 [J].
Ying, QL ;
Nichols, J ;
Chambers, I ;
Smith, A .
CELL, 2003, 115 (03) :281-292