Access to β-Keto Esters by Palladium-Catalyzed Carbonylative Coupling of Aryl Halides with Monoester Potassium Malonates

被引：46

作者：

Korsager, Signe ^{[1
,2
]}

Nielsen, Dennis U. ^{[1
,2
]}

Taaning, Rolf H. ^{[1
,2
]}

Skrydstrup, Troels ^{[1
,2
]}

机构：

[1] Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, Ctr Insoluble Prot Struct inSPIN, DK-8000 Aarhus C, Denmark

[2] Aarhus Univ, Dept Chem, DK-8000 Aarhus C, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 37期

基金：

新加坡国家研究基金会;

关键词：

beta-keto esters; carbonylation; homogeneous catalysis; isotope labeling; palladium; STOICHIOMETRIC CARBON-MONOXIDE; EX-SITU; ACYLATION; ALKOXYCARBONYLATION; GENERATION; SYSTEM; ACIDS;

D O I：

10.1002/anie.201304072

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New tricks for an old dog: The Pd-catalyzed carbonylative α-arylation of monoethyl potassium malonates with aryl bromides and reactive aryl chlorides provides a simple and direct route to aryl β-ketoesters. Because only stoichiometric amounts of carbon monoxide are employed, the method is ideal for the introduction of carbon isotopes into more complex structures. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9763 / 9766

页数：4

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