Surface-Engineered Magnetic Nanoparticles for Molecular Detection of Infectious Agents and Cancer

被引：59

作者：

Elingarami, Sauli ^{[1
,2
]}

Liu, Ming ^{[1
]}

Li, Zhiyang ^{[1
]}

He, Nongyue ^{[1
]}

机构：

[1] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China

[2] Minist Hlth & Social Welf, Dept Prevent Serv TFNC, Dar Es Salaam, Tanzania

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2013年 / 13卷 / 05期

关键词：

Pathogen and Cancer Detection; Nanotechnology; Multifunctional Magnetic Nanoparticles (MNPs); Fabrication of Magnetic Nanoparticles; Self Assembled Monolayers (SAMs); Superparamagnetic; Magnetic Resonance Imaging (MRI); IRON-OXIDE NANOPARTICLES; LOADED BIODEGRADABLE NANOPARTICLES; POLYMERIC MICELLE FORMULATION; ANODIC-STRIPPING VOLTAMMETRY; RESONANCE-IMAGING CONTRAST; ENDOTHELIAL GROWTH-FACTOR; WALLED CARBON NANOTUBES; TARGETED DRUG-DELIVERY; PHASE-II TRIAL; IN-VIVO;

D O I：

10.1166/jnn.2013.7148

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnetic nanoparticles (MNPs), especially superparamagnetic iron oxide nanoparticles (SPIONs), have long been studied as contrast agents for magnetic resonance imaging (MRI). Owing to recent progress in synthesis and surface modification, many new avenues have opened for this class of biomaterials. Such nanoparticles are not merely tiny magnetic crystals, but potential platforms with large surface-to-volume ratios. By taking advantage of the well developed surface chemistry of MNPs, a wide range of functionalities, such as targeting, imaging, detection and therapeutic features, can be loaded onto their surfaces. This property makes magnetic nanoparticles excellent biomaterials for molecular detection of infectious agents and cancer. This short review thus discusses current advances on magnetic nanoparticles as molecular detection agents for infectious agents and cancer.

引用

页码：3204 / 3213

页数：10

共 233 条

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