Anti-inflammatory and immunosuppressive drugs and reproduction

被引：369

作者：

Ostensen, Monika ^{[1
]}

Khamashta, Munther

Lockshin, Michael

Parke, Ann

Brucato, Antonio

Carp, Howard

Doria, Andrea

Rai, Raj

Meroni, Pierluigi

Cetin, Irene

Derksen, Ronald

Branch, Ware

Motta, Mario

Gordon, Caroline

Ruiz-Irastorza, Guillermo

Spinillo, Arsenio

Friedman, Deborah

Cimaz, Rolando

Czeizel, Andrew

Piette, Jean Charles

Cervera, Ricard

Levy, Roger A.

Clementi, Maurizio

De Carolis, Sara

Petri, Michelle

Shoenfeld, Yehuda

Faden, David

Valesini, Guido

Tincani, Angela

机构：

[1] Univ Hosp Bern, Dept Rheumatol & Clin Immunol Allergol, Bern, Switzerland

[2] St Thomas Hosp, Rayne Inst, Lupus Res Inst, London SE1 7EH, England

[3] Cornell Univ, Joan & Sanford Weill Coll Med, Barbara Volcker Ctr Women & Rheumat Dis, Hosp Special Surg, New York, NY USA

[4] Univ Connecticut, Ctr Hlth, Div Rheumat Dis, Dept Med, Farmington, CT USA

[5] Osped Niguarda Ca Granda, Dept Internal Med & Rheumatol, Milan, Italy

[6] Chaim Sheba Med Ctr, Dept Obstet & Gynecol, IL-52621 Tel Hashomer, Israel

[7] Tel Aviv Univ, IL-69978 Tel Aviv, Israel

[8] Univ Padua, Div Rheumatol, Dept Clin & Expt Med, I-35100 Padua, Italy

[9] Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Obstet & Gynaecol, London, England

[10] Univ Milan, Cattedra Med Interna, I-20122 Milan, Italy

[11] Univ Milan, Inst Obstet & Gynecol, I-20122 Milan, Italy

[12] Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, Utrecht, Netherlands

[13] Univ Utah, Hlth Sci Ctr, Dept Obstet & Gynecol, Salt Lake City, UT USA

[14] Spedali Civil Brescia, Neonatol & Neonatal Intens Care Unit, I-25125 Brescia, Italy

[15] Univ Birmingham, Ctr Immune Regulat, Div Immun & Infect, Birmingham, W Midlands, England

[16] Univ Basque Country, Dept Internal Med, Hosp Cruces, Bizkaia, Spain

[17] Univ Pavia, Dept Obstet & Gynecol, I-27100 Pavia, Italy

[18] Univ Texas, Hlth Sci Ctr, Houston, TX USA

[19] Fdn Policlin Mangiagalli, Milan, Italy

[20] Fdn Community Control Hereditary Dis, Budapest, Hungary

[21] Grp Hosp Pitie Salpetriere, Serv Med Interne, F-75634 Paris, France

[22] Hosp Clin Barcelona, Dept Autoimmune Dis, Barcelona, Spain

[23] Univ Estado, Discipline Rheumatol, Fac Ciencias Med, Rio De Janeiro, Brazil

[24] Univ Cattolica Sacro Cuore, Dept Obstet & Gynecol, I-00168 Rome, Italy

[25] Johns Hopkins Univ, Sch Med, Div Rheumatol, Lupus Ctr, Baltimore, MD USA

[26] Tel Aviv Univ, Chaim Sheba Med Ctr, Dept Med, Tel Hashomer, Israel

[27] Tel Aviv Univ, Chaim Sheba Med Ctr, Ctr Autoimmune Dis, Tel Hashomer, Israel

[28] Univ & Hosp Brescia, Dept Obstet & Gynecol, Brescia, Italy

[29] Univ Roma La Sapienza, Cattedra Reumatol, Rome, Italy

来源：

ARTHRITIS RESEARCH & THERAPY | 2006年 / 8卷 / 03期

关键词：

D O I：

10.1186/ar1957

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rheumatic diseases in women of childbearing years may necessitate drug treatment during a pregnancy, to control maternal disease activity and to ensure a successful pregnancy outcome. This survey is based on a consensus workshop of international experts discussing effects of anti-inflammatory, immunosuppressive and biological drugs during pregnancy and lactation. In addition, effects of these drugs on male and female fertility and possible long-term effects on infants exposed to drugs antenatally are discussed where data were available. Recommendations for drug treatment during pregnancy and lactation are given.

引用

页数：19

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