A FACILE ONE-STEP MULTI-COMPONENT APPROACH TOWARD THE SYNTHESIS OF 3-(2-AMINO-4-THIAZOLYL) COUMARINS BY USING TRIMETHYLSILYL ISOTHIOCYANATE AND THEIR ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY

被引：12

作者：

Ramagiri, Raj Kumar ^{[1
]}

Vedula, Rajeswar Rao ^{[1
]}

Thupurani, Murali Krishna ^{[2
]}

机构：

[1] Natl Inst Technol, Dept Chem, Warangal 506004, Andhra Pradesh, India

[2] Chaithanya Postgrad Coll Autonomous, Dept Biotechnol, Hanamkonda, Andhra Pradesh, India

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2015年 / 190卷 / 09期

关键词：

Trimethylsilyl isothiocyanate; coumarin; multi-component reaction; primary amines; REAGENT;

D O I：

10.1080/10426507.2014.990016

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A multi-component synthesis of 3-(2-amino-4-thiazolyl)coumarins has been reported from 3-(2-bromoacetyl)-2H-chromen-2-ones primary amines and using commercially available trimethylsilyl isothiocyanate. The structures of newly synthesized compounds were characterized by their analytical and spectral data. All the title compounds were screened for antioxidant and anti-inflammatory activity. Among the screened compounds, 4b exhibited highest free radical scavenging activity and also 4b was found to be effective in inhibiting the protein denaturation at all tested concentrations.

引用

页码：1393 / 1397

页数：5

共 28 条

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