Protective effect of hydrogen sulfide against neuronal apoptosis via inhibiting neuroinflammation in Parkinson rats

被引:0
|
作者
Jiao, Meizhi [1 ]
Wang, Wen [2 ]
Gao, Zhiyu [3 ]
机构
[1] Zhebei Mingzhou Hosp, Dept Neurol, Huzhou, Zhejiang, Peoples R China
[2] Adventist Hlth Syst Florida Hosp, Internal Med Residency, Altamonte Springs, FL USA
[3] Peking Univ, Dept Neurol, Int Hosp, 1 Life Sci Pk, Beijing 102206, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2019年 / 12卷 / 05期
关键词
Parkinson's disease; hydrogen sulfide; neuronal apoptosis; ROTATION BEHAVIOR; INFLAMMATION; ACTIVATION; TOXICITY; CELLS;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objective: Parkinson's disease (PD) is an age related progressive degenerative disorder. Hydrogen sulfide (H2S) is an endogenous gasotransmitter and exerts crucial physiological functions in central nervous system. Whether H2S protects PD through inhibiting neuro-inflammation remains unknown. Methods: In this study, a 6-OHDA induced PD rat model was established and the protective role of H2S was detected via H2S donor NaHS. Results: Our results demonstrated that H2S inhibited the activation of NF-kappa B signaling pathway, cytokines release in PD rats and significantly reduced the expression of caspase 3, caspase 9 and cytochrome C, and decreased apoptotic cell numbers. Conclusion: H2S may preserve the function of dopaminergic neurons in PD rats possibly through inhibiting neuro-inflammation in Parkinson rats.
引用
收藏
页码:4935 / 4941
页数:7
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