Apoptosis of human leukemia cell line K562 cells induced by hydroxycamptothecine

被引：4

作者：

Shao, ShuLi ^{[1
]}

Zhang, WeiWei ^{[1
]}

Zhao, Wei

Wu, GuangHui

机构：

[1] Qiqihar Univ, Coll Life Sci, Qiqihar 161006, Hei Longjiang P, Peoples R China

来源：

ADVANCED ENGINEERING MATERIALS II, PTS 1-3 | 2012年 / 535-537卷

关键词：

hydroxycamptothecine; apoptosis; human leukemia cell line K562;

D O I：

10.4028/www.scientific.net/AMR.535-537.2420

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

To observe the effects of hydroxycamptothecine(HCPT) on the growth and apoptosis of gastric cancer cell line. The viability of human leukemia cell line K562 was determined by MTT, cell morphology was observed under AO staining and electron microscopy, the apoptosis was measured using flow cytometry analysis. The results indicated that the growth of human leukemia cell line K562 was significantly inhibited by HCPT, and the IC50 was 8.0 mu g/mL. Morphological variations of apoptosis were observed at 48 hours treated with HCPT by AO staining and apoptosis body was observed under electron microscope. The results indicated that HCPT can suppress the growth of human leukemia cell line K562 and induce apoptosis of the cells.

引用

页码：2420 / 2424

页数：5

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