Calcium isolation from large-volume human urine samples for 41Ca analysis by accelerator mass spectrometry

被引：3

作者：

Miller, James J. ^{[1
]}

Hui, Susanta K. ^{[2
]}

Jackson, George S. ^{[3
]}

Clark, Sara P. ^{[4
]}

Einstein, Jane ^{[3
]}

Weaver, Connie M. ^{[3
]}

Bhattacharyya, Maryka H. ^{[1
,4
]}

机构：

[1] Argonne Natl Lab, Lemont, IL 60439 USA

[2] Univ Minnesota, Minneapolis, MN 55455 USA

[3] Purdue Rare Isotope Measurement Lab, W Lafayette, IN 47907 USA

[4] Georgia Regents Univ, Augusta, GA 30912 USA

来源：

APPLIED RADIATION AND ISOTOPES | 2013年 / 78卷

基金：

美国国家卫生研究院;

关键词：

Ca-41; analysis; Accelerator mass spectrometry; Biological samples; Calcium oxalate; Human urine; POSTMENOPAUSAL WOMEN; BONE-RESORPTION; METABOLISM; TRACER; SERUM;

D O I：

10.1016/j.apradiso.2013.04.012

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Calcium oxalate precipitation is the first step in preparation of biological samples for Ca-41 analysis by accelerator mass spectrometry. A simplified protocol for large-volume human urine samples was characterized, with statistically significant increases in ion current and decreases in interference. This large-volume assay minimizes cost and effort and maximizes time after Ca-41 administration during which human samples, collected over a lifetime, provide Ca-41:Ca ratios that are significantly above background. (c) 2013 Elsevier Ltd. All rights reserved.

引用

收藏

页码：57 / 61

页数：5

相关论文

共 21 条

[1] Cadmium osteotoxicity in experimental animals: Mechanisms and relationship to human exposures [J].

Bhattacharyya, Maryka H. .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2009, 238 (03) :258-265

[2] Accelerator mass spectrometry for biomedical research [J].

Brown, K ;

Dingley, KH ;

Turreltaub, KW .

BIOLOGICAL MASS SPECTROMETRY, 2005, 402 :423-443

[3] Soy isoflavones do not affect bone resorption in postmenopausal women:: A dose-response study using a novel approach with 41Ca [J].

Cheong, J. M. K. ;

Martin, B. R. ;

Jackson, G. S. ;

Elmore, D. ;

McCabe, G. P. ;

Nolan, J. R. ;

Barnes, S. ;

Peacock, M. ;

Weaver, C. M. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (02) :577-582

[4] Labeling the human skeleton with 41Ca to assess changes in bone calcium metabolism [J].

Denk, E. ;

Hillegonds, D. ;

Vogel, J. ;

Synal, A. ;

Geppert, C. ;

Wendt, K. ;

Fattinger, K. ;

Hennessy, C. ;

Berglund, M. ;

Hurrell, R. F. ;

Walczyk, T. .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2006, 386 (06) :1587-1602

[5] Evaluation of 41calcium as a new approach to assess changes in bone metabolism:: Effect of a bisphosphonate intervention in postmenopausal women with low bone mass [J].

Denk, Eberhard ;

Hillegonds, Darren ;

Hurrell, Richard F. ;

Vogel, John ;

Fattinger, Karin ;

Hauselmann, Hans J. ;

Kraenzlin, Marius ;

Walczyk, Thomas .

JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (10) :1518-1525

[6] Cadmium Intake and Systemic Exposure in Postmenopausal Women and Age-Matched Men Who Smoke Cigarettes [J].

Ebert-McNeill, Andrea ;

Clark, Sara P. ;

Miller, James J. ;

Birdsall, Paige ;

Chandar, Manisha ;

Wu, Lucia ;

Cerny, Elizabeth A. ;

Hall, Patricia H. ;

Johnson, Maribeth H. ;

Isales, Carlos ;

Chutkan, Norman ;

Bhattacharyya, Maryka H. .

TOXICOLOGICAL SCIENCES, 2012, 130 (01) :191-204

[7] COMPUTER-CONTROLLED ISOTOPE RATIO MEASUREMENTS AND DATA-ANALYSIS [J].

ELMORE, D ;

CONARD, N ;

KUBIK, PW ;

FABRYKAMARTIN, J .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1984, 5 (02) :233-237

[8] CA-41 AS A LONG-TERM BIOLOGICAL TRACER FOR BONE-RESORPTION [J].

ELMORE, D ;

BHATTACHARYYA, MH ;

SACCOGIBSON, N ;

PETERSON, DP .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1990, 52 (3-4) :531-535

[9] 41Ca and accelerator mass spectrometry to monitor calcium metabolism in end stage renal disease patients [J].

Fitzgerald, RL ;

Hillegonds, DJ ;

Burton, DW ;

Griffin, TL ;

Mullaney, S ;

Vogel, JS ;

Deftos, LJ ;

Herold, DA .

CLINICAL CHEMISTRY, 2005, 51 (11) :2095-2102

[10] Human calcium metabolism including bone resorption measured with Ca-41 tracer [J].

Freeman, SPHT ;

King, JC ;

Vieira, NE ;

Woodhouse, LR ;

Yergey, AL .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1997, 123 (1-4) :266-270