The human KB multidrug-resistant cell line KB-C1 is hypersensitive to inhibitors of glycosylation

被引：41

作者：

Bentley, J ^{[1
]}

Quinn, DM ^{[1
]}

Pitman, RS ^{[1
]}

Warr, JR ^{[1
]}

Kellett, GL ^{[1
]}

机构：

[1] UNIV YORK,DEPT BIOL,YORK YO1 5YW,N YORKSHIRE,ENGLAND

来源：

CANCER LETTERS | 1997年 / 115卷 / 02期

关键词：

P-glycoprotein; glucose transporter; tunicamycin; 2-deoxy-D-glucose;

D O I：

10.1016/S0304-3835(97)04739-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have previously shown that the hypersensitivity of KB MDR cells to 2-deoxy-D-glucose is associated with diminished plasma membrane GLUT-1 levels compared with parental, non-MDR cells. Here we report that MDR cells are hypersensitive to the N-linked glycosylation inhibitor tunicamycin, which induces partial inhibition of GLUT-1 glycosylation and diminishes GLUT-1-mediated transport. The effect of tunicamycin, which also enhances the hypersensitivity of MDR cells to 2-deoxy-D-glucose, could not be attributed to alterations in P-glycoprotein activity. The use of agents that act synergistically to diminish the level and activity of GLUT-1 in MDR cells may be of clinical potential. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：221 / 227

页数：7

共 16 条

[1] THE ROLE OF N-GLYCOSYLATION IN THE TARGETING AND STABILITY OF GLUT1 GLUCOSE-TRANSPORTER [J].