Enantioselective Dreiding-Schmidt reactions: Asymmetric synthesis and analysis of alpha-methylene-gamma-butyrolactones

被引：27

作者：

Csuk, R ^{[1
]}

Schroder, C ^{[1
]}

Hutter, S ^{[1
]}

Mohr, K ^{[1
]}

机构：

[1] UNIV HEIDELBERG,PHARM CHEM INST,D-69120 HEIDELBERG,GERMANY

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 09期

关键词：

D O I：

10.1016/S0957-4166(97)00166-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The zinc/silver-graphite mediated Dreiding-Schmidt reactions between aldehydes and the 2-bromomethyl-acrylate derived sultamamides (+)/(-)-28 or (+)/(-)-30 gave the corresponding substituted alpha-methylene-gamma-butyrolactones with ee's up to 90%. Enantiomerically pure compounds were obtained by semipreparative HPLC using a chiral stationary phase. (C) 1997 Elsevier Science Ltd.

引用

页码：1411 / 1429

页数：19

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