Studies toward the Synthesis of Potent Anti-inflammatory Peptides Solomonamides A and B: Synthesis of a Macrocyclic Skeleton and Key Fragment 4-Amino-6-(2′-amino-4′-hydroxyphenyl)-3-hydroxy-2-methyl-6-oxohexanoic Acid (AHMOA)

被引：17

作者：

Kashinath, K. ^{[1
]}

Vasudevan, N. ^{[1
]}

Reddy, D. Srinivasa ^{[1
]}

机构：

[1] CSIR Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 24期

关键词：

ALPHA-AMINO ALDEHYDES; NATURAL-PRODUCTS; DERIVATIVES;

D O I：

10.1021/ol303149k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A first synthetic effort toward total synthesis of highly potent solomonamides is disclosed. An efficient strategy to synthesize this class of compounds, along with the synthesis of a core macrocycle (shown in red) and the key fragment AHMOA, is described.

引用

页码：6222 / 6225

页数：4

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