The intraflagellar transport machinery in ciliary signaling

被引：60
作者：
Mourao, Andre [1 ]
Christensen, Soren T. [2 ]
Lorentzen, Esben [1 ]
机构：
[1] Max Planck Inst Biochem, Dept Struct Cell Biol, Klopferspitz 18, D-82152 Martinsried, Germany
[2] Univ Copenhagen, Dept Biol, Univ Pk 13, DK-2100 Copenhagen, Denmark
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2016年 / 41卷
关键词：
PROTEIN-COUPLED RECEPTORS; BIEDL SYNDROME PROTEINS; IFT-A COMPLEX; PRIMARY-CILIUM; EXTRACELLULAR-MATRIX; REPRESSOR FUNCTIONS; TUBULIN TRANSPORT; CORE COMPLEX; MEMBRANE; BBSOME;
D O I：
10.1016/j.sbi.2016.06.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cilia and flagella on eukaryotic cells are slender microtubule-based projections surrounded by a membrane with a unique lipid and protein composition. It is now appreciated that cilia in addition to their established roles in motility also constitute hubs for cellular signaling by sensing external environmental cues necessary for organ development and maintenance of human health. Pathways reported to rely on the cilium organelle include Hedgehog, TGF-beta, Wnt, PDGFR alpha, integrin and DNA damage repair signaling. An emerging theme in ciliary signaling is the requirement for active transport of signaling components into and out of the cilium proper. Here, we review the current state-of-the-art regarding the importance of intraflagellar transport and BBSome multi-subunit complexes in ciliary signaling.
引用
收藏
页码：98 / 108
页数：11
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