Pyroptosis Plays a Role in Osteoarthritis

被引:177
作者
An, Senbo [1 ]
Hu, Huiyu [2 ]
Li, Yusheng [1 ,3 ]
Hu, Yihe [1 ]
机构
[1] Cent South Univ, Xiangya Hosp, Dept Orthoped, Changsha, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Dept Gen Surg, Changsha, Hunan, Peoples R China
[3] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
pyroptosis; caspase; inflammation; osteoarthritis; INDUCED CELL-DEATH; NLRP3 INFLAMMASOME ACTIVATION; RISK-FACTORS; RHEUMATOID-ARTHRITIS; PATTERN-RECOGNITION; BODY-COMPOSITION; STEM-CELLS; KNEE; PATHOGENESIS; APOPTOSIS;
D O I
10.14336/AD.2019.1127
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Recent studies have revealed novel forms of cell death beyond the canonical types of cellular apoptosis and necrosis, and these novel forms of cell death are induced by extreme microenvironmental factors. Pyroptosis, a type of regulated cell death, occurs when pattern recognition receptors (PRRs) induce the activation of cysteine-aspartic protease 1 (caspase-1) or caspase-11, which can trigger the release of the pyrogenic cytokines interleukin-1 beta (IL-1 beta) and IL-18. Osteoarthritis (OA), the most common joint disease worldwide, is characterized by low-grade inflammation and increased levels of cytokines, including IL-1 beta and IL-18. Additionally, some damaged chondrocytes associated with OA exhibit morphological changes consistent with pyroptosis, suggesting that this form of regulated cell death may contribute significantly to the pathology of OA. This review summarizes the molecular mechanisms of pyroptosis and shows the critical role of NLRP3 (NLR family, pyrin domain containing 3; NLR refers to "nucleotide-binding domain, leucine-rich repeat") inflammasomes. We also provide evidence describing potential role of pyroptosis in OA, including the relationship with OA risk factors and the contribution to cartilage degradation, synovitis and OA pain.
引用
收藏
页码:1146 / 1156
页数:11
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