Innate Lymphoid Cell Interactions with Microbiota: Implications for Intestinal Health and Disease

被引：212

作者：

Sonnenberg, Gregory F. ^{[1
,2
]}

Artis, David ^{[1
,2
,3
]}

机构：

[1] Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Inst Immunol, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA

来源：

IMMUNITY | 2012年 / 37卷 / 04期

基金：

美国国家卫生研究院;

关键词：

NATURAL-KILLER-CELLS; ROR-GAMMA-T; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTOR GATA3; TISSUE-INDUCER CELLS; BACTERIAL TRANSLOCATION; NK CELLS; ATHEROSCLEROTIC LESIONS; COMMENSAL MICROFLORA; DENDRITIC CELLS;

D O I：

10.1016/j.immuni.2012.10.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mammalian intestine harbors trillions of beneficial commensal bacteria that are essential for the development of the immune system and for maintenance of physiologic processes in multiple organs. However, numerous chronic infectious, inflammatory, and metabolic diseases in humans have been associated with alterations in the composition or localization of commensal bacteria that result in dysregulated host-commensal bacteria relationships. The mammalian immune system plays an essential role in regulating the acquisition, composition, and localization of commensal bacteria in the intestine. Emerging research has implicated innate lymphoid cells (ILCs) as a critical immune cell population that orchestrates some of these host-commensal bacteria relationships that can impact immunity, inflammation, and tissue homeo-stasis in the intestine. This review will discuss reciprocal interactions between intestinal commensal bacteria and ILCs in the context of health and disease.

引用

页码：601 / 610

页数：10

共 115 条

[1] Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity [J].

Abt, Michael C. ;

Osborne, Lisa C. ;

Monticelli, Laurel A. ;

Doering, Travis A. ;

Alenghat, Theresa ;

Sonnenberg, Gregory F. ;

Paley, Michael A. ;

Antenus, Marcelo ;

Williams, Katie L. ;

Erikson, Jan ;

Wherry, E. John ;

Artis, David .

IMMUNITY, 2012, 37 (01) :158-170

[2] Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept [J].

Amar, J. ;

Serino, M. ;

Lange, C. ;

Chabo, C. ;

Iacovoni, J. ;

Mondot, S. ;

Lepage, P. ;

Klopp, C. ;

Mariette, J. ;

Bouchez, O. ;

Perez, L. ;

Courtney, M. ;

Marre, M. ;

Klopp, P. ;

Lantieri, O. ;

Dore, J. ;

Charles, M. A. ;

Balkau, B. ;

Burcelin, R. .

DIABETOLOGIA, 2011, 54 (12) :3055-3061

[3] Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Shima, Tatsuichiro ;

Imaoka, Akemi ;

Kuwahara, Tomomi ;

Momose, Yoshika ;

Cheng, Genhong ;

Yamasaki, Sho ;

Saito, Takashi ;

Ohba, Yusuke ;

Taniguchi, Tadatsugu ;

Takeda, Kiyoshi ;

Hori, Shohei ;

Ivanov, Ivaylo I. ;

Umesaki, Yoshinori ;

Itoh, Kikuji ;

Honda, Kenya .

SCIENCE, 2011, 331 (6015) :337-341

[4] Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis [J].

Bouskra, Djahida ;

Brezillon, Christophe ;

Berard, Marion ;

Werts, Catherine ;

Varona, Rosa ;

Boneca, Ivo Gomperts ;

Eberl, Gerard .

NATURE, 2008, 456 (7221) :507-U34

[5] IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration [J].

Brand, S ;

Beigel, F ;

Olszak, T ;

Zitzmann, K ;

Eichhorst, ST ;

Otte, JM ;

Diepolder, H ;

Marquardt, A ;

Jagla, W ;

Popp, A ;

Leclair, S ;

Herrmann, K ;

Seiderer, J ;

Ochsenkühn, T ;

Göke, B ;

Auernhammer, CJ ;

Dambacher, J .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2006, 290 (04) :G827-G838

[6] Microbial Translocation Across the GI Tract [J].

Brenchley, Jason M. ;

Douek, Daniel C. .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30, 2012, 30 :149-173

[7] Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology [J].

Buonocore, Sofia ;

Ahern, Philip P. ;

Uhlig, Holm H. ;

Ivanov, Ivaylo I. ;

Littman, Dan R. ;

Maloy, Kevin J. ;

Powrie, Fiona .

NATURE, 2010, 464 (7293) :1371-1375

[8] Human natural killer cells [J].

Caligiuri, Michael A. .

BLOOD, 2008, 112 (03) :461-469

[9] A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity [J].

Cella, Marina ;

Fuchs, Anja ;

Vermi, William ;

Facchetti, Fabio ;

Otero, Karel ;

Lennerz, Jochen K. M. ;

Doherty, Jason M. ;

Mills, Jason C. ;

Colonna, Marco .

NATURE, 2009, 457 (7230) :722-725

[10] Direct Recognition of Fusobacterium nucleatum by the NK Cell Natural Cytotoxicity Receptor NKp46 Aggravates Periodontal Disease [J].

Chaushu, Stella ;

Wilensky, Asaf ;

Gur, Chamutal ;

Shapira, Lior ;

Elboim, Moran ;

Halftek, Gili ;

Polak, David ;

Achdout, Hagit ;

Bachrach, Gilad ;

Mandelboim, Ofer .

PLOS PATHOGENS, 2012, 8 (03)

← 1 2 3 4 5 6 7 8 9 10 →