The role of action potential alternans in the initiation of atrial fibrillation in humans: a review and future directions

被引：42
作者：
Franz, Michael R. [1 ]
Jamal, Sameer M. [2 ]
Narayan, Sanjiv M. [3 ,4 ]
机构：
[1] VA Med Ctr, Div Cardiol, Washington, DC 20422 USA
[2] Washington Hosp Ctr, Div Cardiol, Washington, DC 20010 USA
[3] Univ Calif San Diego, San Diego, CA 92161 USA
[4] Vet Affairs Med Ctr, San Diego, CA 92161 USA
来源：
EUROPACE | 2012年 / 14卷
关键词：
Atrial fibrillation; Electrical remodelling; Monophasic action potential (MAP); Action potential duration (APD); Electrical restitution curve (ERC); Rate maladaptation; Action potential duration (APD) alternans; Alternans; Electrical heterogeneity; CYCLE LENGTH DEPENDENCE; ELECTRICAL RESTITUTION; REPOLARIZATION ALTERNANS; STEADY-STATE; K+ CHANNEL; VENTRICULAR-FIBRILLATION; DISCORDANT ALTERNANS; RATE ADAPTATION; MECHANISMS; MODEL;
D O I：
10.1093/europace/eus273
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This review highlights the role of atrial monophasic action potential duration (APD) in understanding atrial electrical properties in paroxysmal, persistent, and permanent atrial fibrillation (AF) states. Alternans of APD and rate maladaptation in a spatially divergent way appear mechanistically involved in AF initiation, development, and persistence. The underlying pathophysiology warrants further investigation.
引用
收藏
页码：V58 / V64
页数：7
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