Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia

被引：3

作者：

Dias, Rosane Borges ^{[1
]}

Valverde, Ludmila de Faro ^{[1
]}

Schlaepfer Sales, Caroline Brandi ^{[1
]}

Nazare Guimaraes, Vanessa Sousa ^{[1
]}

Cabral, Marcia Grillo ^{[3
]}

de Aquino Xavier, Flavia Calo ^{[2
]}

dos Santos, Jean Nunes ^{[2
]}

Goncalves Ramos, Eduardo Antonio ^{[1
]}

Gurgel Rocha, Clarissa Araujo ^{[1
,2
]}

机构：

[1] Fundacao Oswaldo Cruz, Lab Pathol & Mol Biol, Salvador, BA, Brazil

[2] Univ Fed Bahia, Sch Dent, Lab Oral Surg Pathol, BR-41170290 Salvador, BA, Brazil

[3] Univ Fed Rio de Janeiro, Sch Dent, Dept Pathol & Oral Diag, Rio De Janeiro, Brazil

来源：

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2016年 / 24卷 / 08期

关键词：

oral epithelial dysplasia; Hedgehog proteins; premalignant lesion; SQUAMOUS-CELL CARCINOMA; SIGNALING PATHWAY; CYCLIN D1; CANCER; GENE; ACTIVATION; BREAST; INVOLVEMENT; MECHANISMS; NETWORK;

D O I：

10.1097/PAI.0000000000000225

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The aim of this study was to characterize the profile of the proteins involved in the Hedgehog signaling pathway to aid in the understanding of the pathogenesis of oral epithelial dysplasia (OED). The proteins SHH, PTCH1, HHIP, SUFU, GLI1, and cyclin D1 were evaluated by immunohistochemistry in 25 cases of OED, 4 of non-neoplasic oral mucosa, 8 of inflammatory fibrous hyperplasia and 5 of hyperkeratosis. SHH proteins were predominant in OED cases. Although PTCH1 protein was observed in all cases, this molecule was more highly expressed in OED. The inhibitor protein SUFU was present in OED and HHIP protein was overexpressed in OED. GLI1 proteins were predominantly found in the nuclei of epithelial cells in OED. Basal and suprabasal cells in the epithelial lining were positive for cyclin D1 only in OED. In conclusion, comparative analysis of the proteins involved in the Hedgehog pathway suggests that enhanced expression of these proteins can play an important role in the biological behavior of OED.

引用

页码：595 / 602

页数：8

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