Excited-State Dynamics of Bis-dehydroxycurcumin Carboxylic Acid, a Water-Soluble Derivative of the Photosensitizer Curcumin

被引：19

作者：

Nardo, Luca ^{[1
]}

Maspero, Angelo ^{[1
]}

Selva, Marco ^{[1
]}

Bondani, Maria ^{[2
]}

Palmisano, Giovanni ^{[1
]}

Ferrari, Erika ^{[3
]}

Saladini, Monica ^{[3
]}

机构：

[1] Univ Insubria, Dept Sci & High Technol, I-22100 Como, Italy

[2] CNR, Inst Photon & Nanotechnol, I-22100 Como, Italy

[3] Univ Modena & Reggio Emilia, Dept Chem & Geol Sci, I-41125 Modena, Italy

来源：

JOURNAL OF PHYSICAL CHEMISTRY A | 2012年 / 116卷 / 37期

关键词：

PHOTOPHYSICAL PROPERTIES; ANTIOXIDANT ACTIVITY; SOLVATION DYNAMICS; CRYSTAL-STRUCTURE; BETA; CYTOTOXICITY; INHIBITION; PARAMETERS; SOLVENT; HIV-1;

D O I：

10.1021/jp307928a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Bis-dehydroxycurcumin carboxylic acid (K2A23) is a synthetic curcuminoid designed to exhibit enhanced water solubility and photosensitizing potential with respect to natural curcumin. In this work, the tendency of the compound to form intra- and intermolecular hydrogen bonds in the ground state is studied by UV-visible absorption and by nuclear magnetic resonance (NMR). The excited-state dynamics of the drug are probed in different environments by means of time-correlated single-photon counting measurements and related to its hydrogen bonding affinity in the excited state.

引用

页码：9321 / 9330

页数：10

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