Serum of Babesia rodhaini infected mice down regulates catalase activity of healthy erythrocytes

被引：2

作者：

Chiou, Shih-Pin ^{[1
]}

Yokoyama, Naoaki ^{[2
]}

Igarashi, Ikuo ^{[2
]}

Kitoh, Katsuya ^{[1
,3
]}

Takashima, Yasuhiro ^{[1
,3
]}

机构：

[1] Gifu Univ, Dept Vet Parasitol Dis, United Grad Sch Vet Sci, Gifu 5011193, Japan

[2] Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Obihiro, Hokkaido 0808555, Japan

[3] Gifu Univ, Dept Vet Parasitol Dis, Gifu 5011193, Japan

来源：

EXPERIMENTAL PARASITOLOGY | 2012年 / 132卷 / 03期

关键词：

Babesiosis; Anemia; Hemolysis; Catalase; Oxidative stress; ANTIERYTHROCYTE MEMBRANE ANTIBODY; LIPID-PEROXIDATION; HEMOLYTIC-ACTIVITY; OXIDATIVE STRESS; GIBSONI; DOGS; ANTIOXIDANTS; MACROPHAGES; REACTIVITY; MECHANISMS;

D O I：

10.1016/j.exppara.2012.08.004

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Hemolytic activity for animals infected with various Babesia species is well reported. In this study, we confirmed that serum of Babesia rodhaini-infected mice also showed hemolytic activity. Erythrocytes from non-infected mice were lysed by co-incubation with B. rodhaini-infected serum. Catalase activity of the non-infected target erythrocytes was suppressed after this co-incubation with the hemolytic serum of B. rodhaini-infected mice. Furthermore, serum hemolytic activity was inhibited when target erythrocytes were incubated with hemolytic serum in the presence of exogenous catalase. Our study indicated that hemolytic serum can down-regulate the antioxidant capacity of non-infected healthy erythrocytes, possibly as a result of catalase activity, thereby leading to hemolysis. (c) 2012 Elsevier Inc. All rights reserved.

引用

页码：327 / 333

页数：7

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