Transcutaneous Electrical Nerve Stimulation in Nerve Regeneration: A Systematic Review of In Vivo Animal Model Studies

被引:15
作者
Belen Alarcon, Josefa [1 ]
Belen Chuhuaicura, Priscila [1 ]
Anne Sluka, Kathleen [2 ]
Vance, Carol G. T. [2 ]
Sasoli Fazan, Valeria Paula [3 ]
Alejandra Godoy, Karina [4 ]
Eduardo Fuentes, Ramon [1 ,5 ]
Jose Dias, Fernando [1 ,5 ]
机构
[1] Univ La Frontera, Dent Sch, Res Ctr Dent Sci CICO UFRO, Fac Odontol, Temuco, Chile
[2] Univ Iowa, Dept Phys Therapy & Rehabil Sci, Pain Res Program, Iowa City, IA USA
[3] Univ Sao Paulo FMRP USP, Sch Med Ribeirao Preto, Dept Surg & Anat, Ribeirao Preto, Brazil
[4] Univ La Frontera, Sci & Technol Bioresource Nucleus BIOREN UFRO, Temuco, Chile
[5] Univ La Frontera, Dent Sch, Dept Integral Adults Dent, Fac Odontol, Av Francisco Salazar, Temuco 01145, Chile
来源
NEUROMODULATION | 2022年 / 25卷 / 08期
关键词
Electrical stimulation; nerve regeneration; physical therapy; rehabilitation; TENS; GUIDE CONDUIT; INJURY; REPAIR; TISSUE; MECHANISMS; FREQUENCY;
D O I
10.1016/j.neurom.2021.12.009
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objective: Transcutaneous electrical nerve stimulation (TENS) is a noninvasive electrical stimulation therapy indicated for pain control that has been applied for the regeneration of nerves. This systematic review aimed to analyze the evidence on TENS effectiveness on nerve regeneration. Materials and Methods: A systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria: PubMed/MEDLINE, Web of Science, ScienceDirect, and SciELO data bases. Primary research that evaluated TENS on nerve regeneration was considered. Results: Several studies have investigated the use of TENS for pain treatment. A total of six animal studies analyzed TENS for nerve regeneration. The selected articles showed high quality (Animal Research: Reporting of In Vivo Experiments guidelines), with many unclear points related to bias opportunities (Systematic Review Center for Laboratory Animal Experimentation Risk of Bias tool). In general, TENS accelerated functional and motor recovery and increased axon quantity and diameter. More specifically, the application of low-frequency TENS resulted in a continuous basal lamina; a higher density of fibers with normal diameters, indicating normal myelination, showed signs of deterioration and delayed nerve regeneration. In contrast, the high-frequency TENS application stimulated motor regeneration and increased the diameter of the regenerated axons but revealed a small number of axons, demyelination, dark axoplasm, and an increase in the predisposition of neuropathic pain. Conclusions: Although there is some heterogeneous evidence in animal research, TENS seems to be a promising treatment for nerve injury that should be better explored. It is still necessary to improve the analysis of its application parameters, which can lead to the most satisfactory regeneration results and improve the understanding of its mechanisms on peripheral nerve
引用
收藏
页码:1248 / 1258
页数:11
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