Long range chromatin interactions involved in gene regulation

被引:45
作者
Bartkuhn, Marek [1 ]
Renkawitz, Rainer [1 ]
机构
[1] Univ Giessen, Inst Genet, D-35392 Giessen, Germany
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2008年 / 1783卷 / 11期
关键词
Chromatin; Three-dimensional interaction; Enhancer; Imprinting; CTCF;
D O I
10.1016/j.bbamcr.2008.07.011
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Long-distance chromatin interaction has been proposed and demonstrated for enhancer elements separated from the gene by hundreds or thousands of base pairs. This paved the way for the detection of additional enhancer properties, such as the regulation of interaction, and the contacting of genes in trans on other chromosomes. The outspread arrangement of regulatory elements and transcription units requires insulators to prevent the functional interference of enhancer elements with inappropriate promoters. Apparently, insulators mediate differential chromatin folding to allow or to prevent enhancers from contacting specific promoters. The factor CTCF is often involved in bridging separated chromatin regions. In addition to interchromosomal contacts, intrachromosomal interactions have been demonstrated for genes with a similar regulation, such as active genes, estrogen induced genes and imprinted genes. With more sophisticated and sensitive methods combined with deep sequencing and array technology, a huge number of long range interactions can expected to be characterized in the near future. (c) 2008 Elsevier B.V. All rights reserved
引用
收藏
页码:2161 / 2166
页数:6
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