Friend or Foe: The Protective and Pathological Roles of Inducible Bronchus-Associated Lymphoid Tissue in Pulmonary Diseases

被引:48
|
作者
Marin, Nancy D. [1 ]
Dunlap, Micah D. [1 ,2 ]
Kaushal, Deepak [3 ]
Khader, Shabaana A. [1 ]
机构
[1] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
[3] Tulane Natl Primate Res Ctr, Div Bacteriol & Parasitol, New Orleans, LA 70118 USA
来源
JOURNAL OF IMMUNOLOGY | 2019年 / 202卷 / 09期
基金
美国国家卫生研究院;
关键词
CD4; T-CELLS; MYCOBACTERIUM-TUBERCULOSIS; B-CELLS; FOLLICLE FORMATION; BALT FORMATION; TH17; CELLS; IMMUNITY; INTERLEUKIN-17; IL-17; LUNG;
D O I
10.4049/jimmunol.1801135
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Inducible bronchus-associated lymphoid tissue (iBALT) is a tertiary lymphoid structure that resembles secondary lymphoid organs. iBALT is induced in the lung in response to Ag exposure. In some cases, such as infection with Mycobacterium tuberculosis, the formation of iBALT structure is indicative of an effective protective immune response. However, with persistent exposure to Ags during chronic inflammation, allergy, or autoimmune diseases, iBALT may be associated with exacerbation of inflammation. iBALT is characterized by well-organized T and B areas enmeshed with conventional dendritic cells, follicular dendritic cells, and stromal cells, usually located surrounding airways or blood vessels. Several of the molecular signals and cellular contributors that mediate formation of iBALT structures have been recently identified. This review will outline the recent findings associated with the formation and maintenance of iBALT and their contributions toward a protective or pathogenic function in pulmonary disease outcome.
引用
收藏
页码:2519 / 2526
页数:8
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