Natural Products: Promising Resources for Cancer Drug Discovery

被引：148

作者：

Mondal, Susmita ^{[1
]}

Bandyopadhyay, Santu ^{[1
]}

Ghosh, Mrinal K. ^{[1
]}

Mukhopadhyay, Sibabrata ^{[3
]}

Roy, Siddhartha ^{[2
]}

Mandal, Chitra ^{[1
]}

机构：

[1] CSIR, Indian Inst Chem Biol, Canc & Cell Biol Div, Kolkata 700032, India

[2] CSIR, Indian Inst Chem Biol, Struct Biol & Bioinformat Div, Kolkata 700032, India

[3] CSIR, Indian Inst Chem Biol, Div Chem, Kolkata 700032, India

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2012年 / 12卷 / 01期

关键词：

Apoptosis; Chemoprevention; Immunotherapy; Lead molecule; Medicinal plants; CELL-CYCLE ARREST; NITROSODIETHYLAMINE-INDUCED HEPATOCARCINOGENESIS; BUCCAL POUCH CARCINOGENESIS; NEEM LIMONOIDS AZADIRACHTIN; INDUCED SKIN CARCINOGENESIS; INDUCED LUNG CARCINOGENESIS; ELECTRON-TRANSPORT CHAIN; INDIAN MEDICINAL-PLANT; DIALLYL DISULFIDE DADS; LEUKEMIA HL-60 CELLS;

D O I：

10.2174/187152012798764697

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Natural products are important sources of anti-cancer lead molecules. Many successful anti-cancer drugs are natural products or their analogues. Many more are under clinical trials. The present review focuses on chemopreventive and anti-cancer activities of polar and non-polar extracts, semi purified fractions and pure molecules from terrestrial plants of India reported between 2005 and 2010 emphasizing possible mechanisms of action of pure molecules.

引用

页码：49 / 75

页数：27

共 169 条

[1] EXPLORATION OF NATURE [J].

ABELSON, PH .

SCIENCE, 1990, 250 (4984) :1069-1069

[2] Theaflavins retard human breast cancer cell migration by inhibiting NF-κB via p53-ROS cross-talk [J].

Adhikary, Arghya ;

Mohanty, Suchismita ;

Lahiry, Lakshmishri ;

Hossain, Dewan Md Sakib ;

Chakraborty, Samik ;

Das, Tanya .

FEBS LETTERS, 2010, 584 (01) :7-14

[3] Garlic oil ameliorates ferric nitrilotriacetate (Fe-NTA)-induced damage and tumor promotion: Implications for cancer prevention [J].

Agarwal, Mukesh Kumar ;

Iqbal, Mohammad ;

Athar, Mohammad .

FOOD AND CHEMICAL TOXICOLOGY, 2007, 45 (09) :1634-1640

[4]

[Anonymous], BASIC CLIN PHARM TOX

[5]

[Anonymous], INVEST NEW DRUGS

[6]

[Anonymous], FOYES PRINCIPLES MED

[7] Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin [J].

Arora, Annu ;

Kalra, Neetu ;

Shukla, Yogeshwer .

CANCER LETTERS, 2006, 242 (01) :28-36

[8] Chemoprevention of rat prostate carcinogenesis by diallyl disulfide, an organosulfur compound of garlic [J].

Arunkumar, A ;

Vijayababu, MR ;

Venkataraman, P ;

Senthilkumar, K ;

Arunakaran, J .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (02) :375-379

[9] Growth suppressing effect of garlic compound diallyl disulfide on prostate cancer cell line (PC-3) in vitro [J].

Arunkumar, A ;

Vijayababu, MR ;

Kanagaraj, P ;

Balasubramanian, K ;

Aruldhas, MM ;

Arunakaran, J .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, 28 (04) :740-743

[10] Induction of apoptosis and histone hyperacetylation by diallyl disulfide in prostate cancer cell line PC-3 [J].

Arunkumar, Arumugam ;

Vijayababu, Marati Radhakrishnan ;

Gunadharini, Nandagopal ;

KrIshnamoorthy, Gunasekaran ;

Arunakaran, Jagadeesan .

CANCER LETTERS, 2007, 251 (01) :59-67

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