MANAGEMENT OF ENDOCRINE DISEASE The role of surgical adrenalectomy in primary aldosteronism

被引：27

作者：

Hundemer, Gregory L. ^{[1
]}

Vaidya, Anand ^{[2
]}

机构：

[1] Univ Ottawa, Ottawa Hosp, Res Inst, Div Nephrol, Ottawa, ON, Canada

[2] Harvard Med Sch, Ctr Adrenal Disorders, Div Endocrinol Diabet & Hypertens, Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2020年 / 183卷 / 06期

基金：

美国国家卫生研究院;

关键词：

QUALITY-OF-LIFE; UNILATERAL PRIMARY ALDOSTERONISM; BILATERAL PRIMARY ALDOSTERONISM; TREATED PRIMARY ALDOSTERONISM; ESSENTIAL-HYPERTENSION; CARDIOVASCULAR EVENTS; METABOLIC SYNDROME; CLINICAL-OUTCOMES; DIABETES-MELLITUS; CORTISOL EXCESS;

D O I：

10.1530/EJE-20-0863

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Primary aldosteronism is common and contributes to adverse cardiovascular, kidney, and metabolic outcomes. When instituted early and effectively, targeted therapies can mitigate these adverse outcomes. Surgical adrenalectomy is among the most effective treatments because it has the potential to cure, or attenuate the severity of, pathologic aldosterone excess, resulting in a host of biochemical and clinical changes that improve health outcomes. Herein, we review the role of surgical adrenalectomy in primary aldosteronism while emphasizing the physiologic ramifications of surgical intervention, and compare these to other targeted medical therapies for primary aldosteronism. We specifically review the role of curative adrenalectomy for unilateral primary aldosteronism, the role of non-curative adrenalectomy for bilateral primary aldosteronism, and how these interventions influence biochemical and clinical outcomes in relation to medical therapies for primary aldosteronism.

引用

页码：R183 / R194

页数：12

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