The impact of mode of delivery and gestational age on cord blood hematopoietic stem/progenitor cells

被引：14
作者：
Dimitriou, H
Perdikogianni, C
Stiakaki, E
Vorgia, P
Hatzidaki, E
Kalmanti, M [1 ]
机构：
[1] Univ Hosp Heraklion, Dept Paediat Haematol Oncol, Iraklion 71110, Crete, Greece
[2] Univ Crete, Sch Med, Dept Paediat Haematol Oncol, Iraklion, Crete, Greece
来源：
ANNALS OF HEMATOLOGY | 2006年 / 85卷 / 06期
关键词：
cord blood; perinatal factors; progenitor cell yield; transplantation;
D O I：
10.1007/s00277-006-0089-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Human cord blood has been successfully used as an alternative source of hematopoietic stem cells suitable for transplantation. The aim of this study was to assess the impact of gestational age and the mode of delivery on cord blood hematopoietic stem/progenitor cell characteristics. The mode of delivery does not seem to affect either the replating capacity of hematopoietic progenitors colony-forming unit-granulocyte-macrophage or the cord blood content in CD34(+) cells. The higher percentage of CD34(+) cells in cord blood from preterm deliveries compared to full-term ones indicates that hematopoietic progenitors from preterm cord blood may be suitable for transplantation. These findings should be taken into consideration when selection of cord blood units is required for potential use in transplantation.
引用
收藏
页码：381 / 385
页数：5
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