Reduction of Hepatitis A Virus on FRhK-4 Cells Treated with Korean Red Ginseng Extract and Ginsenosides

被引：44

作者：

Lee, Min Hwa ^{[1
]}

Lee, Bog-Hieu ^{[1
]}

Lee, Sanghyun ^{[2
,3
]}

Choi, Changsun ^{[1
]}

机构：

[1] Chung Ang Univ, Dept Food & Nutr, Ansung 456756, South Korea

[2] Chung Ang Univ, Dept Integrat Plant Sci, Ansung 456756, South Korea

[3] Chung Ang Univ, Ansung 456756, South Korea

来源：

JOURNAL OF FOOD SCIENCE | 2013年 / 78卷 / 09期

关键词：

antiviral; hepatitis A virus; ginsenoside Rb1; ginsenoside Rg1; red ginseng; FOODBORNE VIRAL SURROGATES; POMEGRANATE POLYPHENOLS; FELINE CALICIVIRUS; ANTIVIRAL ACTIVITY; IN-VITRO; EPIDEMIOLOGY; JUICE; IDENTIFICATION; PHARMACOLOGY; ASSAY;

D O I：

10.1111/1750-3841.12205

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Red ginseng has a variety of bioactive functions and is widely used as an oriental medicinal herb and food ingredient. The aim of this study was to investigate the antiviral effect of red ginseng extract and ginsenosides against hepatitis A virus (HAV). To examine the antiviral effect against HAV, 0 to 10 mu g/mL of red ginseng and purified ginsenoside Rb1 and Rg1 were pre-treated or co-treated on FRhK-4 cells. The HAV titer decreased significantly in all groups pretreated with red ginseng or purified ginsenosides. The reduction of HAV was significant in FRhK-4 cells pre-treated only with red ginseng. Our results showed that red ginseng and ginsenoside Rg1 and Rb1 could decrease HAV titers.

引用

页码：M1412 / M1415

页数：4

共 9 条

[1] Antiviral Effect of Korean Red Ginseng Extract and Ginsenosides on Murine Norovirus and Feline Calicivirus as Surrogates for Human Norovirus
Lee, Min Hwa
Lee, Bog-Hieu
Jung, Ji-Youn
Cheon, Doo-Sung
Kim, Kyung-Tack
Choi, Changsun
JOURNAL OF GINSENG RESEARCH, 2011, 35 (04) : 429 - 435
[2] Expression of antiviral cytokines in Crandell-Reese feline kidney cells pretreated with Korean red ginseng extract or ginsenosides
Lee, Min Hwa
Seo, Dong Joo
Kang, Ju-Hee
Oh, Seung Hyun
Choi, Changsun
FOOD AND CHEMICAL TOXICOLOGY, 2014, 70 : 19 - 25
[3] Cellular Uptake of Ginsenosides in Korean White Ginseng and Red Ginseng and Their Apoptotic Activities in Human Breast Cancer Cells
Lee, Jung Il
Ha, Young Wan
Choi, Tae Won
Kim, Hyun Jung
Kim, Sung-Moo
Jang, Hyeung-Jin
Choi, Jung-Hye
Choi, Man Ho
Chung, Bong Chul
Sethi, Gautam
Kim, Sung-Hoon
Ahn, Kyoo Seok
Choi, Seung-Hoon
Shim, Bum Sang
Ahn, Kwang Seok
PLANTA MEDICA, 2011, 77 (02) : 133 - 140
[4] PRIMARY ISOLATION OF A BRAZILIAN STRAIN OF HEPATITIS-A VIRUS (HAF-203) AND GROWTH IN A PRIMATE CELL-LINE (FRHK-4)
GASPAR, AMC
VITRAL, CL
YOSHIDA, CFT
SCHATZMAYR, HG
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1992, 25 (07) : 697 - 705
[5] Korean red ginseng extract induces apoptosis and decreases telomerase activity in human leukemia cells
Park, Sang Eun
Park, Cheol
Kim, Sun Hee
Hossain, Mohammad Akbar
Kim, Min Young
Chung, Hae Young
Son, Woo Sung
Kim, Gi-Young
Choi, Yung Hyun
Kim, Nam Deuk
JOURNAL OF ETHNOPHARMACOLOGY, 2009, 121 (02) : 304 - 312
[6] Korean Red Ginseng water extract arrests growth of xenografted lymphoma cells
Park, Jae Gwang
Son, Young-Jin
Aravinthan, Adithan
Kim, Jong-Hoon
Cho, Jae Youl
JOURNAL OF GINSENG RESEARCH, 2016, 40 (04) : 431 - 436
[7] Induction of Thioredoxin Reductase 1 by Korean Red Ginseng Water Extract Regulates Cytoprotective Effects on Human Endothelial Cells
Park, Hye Rim
Lee, Seung Eun
Yang, Hana
Son, Gun Woo
Jin, Young-Ho
Park, Yong Seek
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2015, 2015
[8] Subchronic oral toxicity study of Korean red ginseng extract in Sprague-Dawley rats with a 4-week recovery period
Park, Sang-Jin
Noh, JeongHo
Jeong, Eun Ju
Kim, Yong-Soon
Han, Byung-Cheol
Lee, Seung-Ho
Moon, Kyoung-Sik
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2018, 92 : 83 - 93
[9] Korean red ginseng extract induces proliferation to differentiation transition of human acute promyelocytic leukemia cells via MYC-SKP2-CDKN1B axis
Jo, Sungsin
Lee, Hongki
Kim, Sojin
Lee, Chang Ho
Chung, Heekyoung
JOURNAL OF ETHNOPHARMACOLOGY, 2013, 150 (02) : 700 - 707

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