Caffeoyl Triterpenoid Esters as Potential Anti-ischemic Stroke Agents from Celastrus orbiculatus

被引：13

作者：

Li, Jin-Long ^{[1
]}

Wu, Lei ^{[2
]}

Wu, Jian ^{[1
]}

Feng, Hong-Xuan ^{[2
]}

Wang, Hong-Min ^{[1
]}

Fu, Yan ^{[2
]}

Zhang, Ru-Jun ^{[1
]}

Zhang, Hai-Yan ^{[2
]}

Zhao, Wei-Min ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 11期

基金：

中国国家自然科学基金;

关键词：

TISSUE-PLASMINOGEN ACTIVATOR; ACUTE ISCHEMIC-STROKE; SESQUITERPENES; DEFICITS; DISEASE; INJURY; SEEDS;

D O I：

10.1021/acs.jnatprod.6b00314

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new triterpenoids, celastrusins A-C (1-3), together with 3-O-caffeoyl-alpha-amyrin (4) were isolated from the root bark of Celastrus orbiculatus. Their structures were identified by spectroscopic analysis, X-ray crystallography using Cu K alpha radiation, and the comparison of both observed and reported spectroscopic data. An in vitro bioassay revealed that the caffeoyl triterpenoid esters 1, 3, and 4 possess neuroprotective effects against oxygen-glucose deprivation (OGD) induced SH-SYSY cell damage. Further animal studies indicated that compound 1 significantly reduced brain infarction after transient middle cerebral artery occlusion (MCAO) in rats using a 10 mg/kg (i.v.) dose.

引用

页码：2774 / 2779

页数：6

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