Increased Risk of Ischemic Stroke in Young Patients with Ankylosing Spondylitis: A Population-Based Longitudinal Follow-Up Study

被引：23

作者：

Lin, Chia-Wei ^{[1
]}

Huang, Ya-Ping ^{[2
]}

Chiu, Yueh-Hsia ^{[3
]}

Ho, Yu-Tsun ^{[1
]}

Pan, Shin-Liang ^{[1
,4
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan

[2] Natl Taiwan Univ Hosp, Dept Phys Med & Rehabil, Yu Lin Branch, Yunlin, Taiwan

[3] Chang Gung Univ, Dept & Grad Inst Hlth Care Management, Tao Yuan, Taiwan

[4] Natl Taiwan Univ, Coll Med, Dept Phys Med & Rehabil, Taipei 10764, Taiwan

来源：

PLOS ONE | 2014年 / 9卷 / 04期

关键词：

CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; ATHEROSCLEROSIS; PREVALENCE; RECOMMENDATIONS; MANIFESTATIONS; INFLAMMATION; MANAGEMENT; PROFILE; UPDATE;

D O I：

10.1371/journal.pone.0094027

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Prospective data on the association between ischemic stroke and ankylosing spondylitis (AS) in the young are sparse. The purpose of this population-based, age- and sex-matched longitudinal follow-up study was to investigate the risk of developing ischemic stroke in young patients with AS. Methods: A total of 4562 patients aged 18- to 45-year-old with at least two ambulatory visits in 2001 with a principal diagnosis of AS were enrolled in the AS group. The non-AS group consisted of 22810 age- and sex-matched, randomly sampled subjects without AS. The two-year ischemic stroke-free survival rate for each group were calculated using the Kaplan-Meier method. Cox proportional hazards regression analysis was used to estimate the hazard ratio of ischemic stroke after adjusting for demographic and clinical covariates. Results: During follow-up, 21 patients in the AS group and 53 in the non-AS group developed ischemic stroke. The ischemic stroke-free survival rate over the 2 year follow-up was lower in the AS group than the non-AS group (p = 0.0021). The crude hazard ratio of ischemic stroke for the AS group was 1.98 (95% CI, 1.20-3.29; p = 0.0079) and the adjusted hazard ratio after controlling for demographic and comorbid medical disorders was 1.93 (95% CI, 1.16-3.20; p = 0.0110). Conclusion: Our study showed an increased risk of developing ischemic stroke in young patients with AS.

引用

页数：6

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