Suppression of androgen receptor signaling and prostate specific antigen expression by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells

被引：70
作者：
Chuu, Chih-Pin [1 ]
Chen, Rou-Yu [1 ]
Kokontis, John M. [1 ]
Hiipakka, Richard A. [1 ]
Liao, Shutsung [1 ]
机构：
[1] Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA
来源：
CANCER LETTERS | 2009年 / 275卷 / 01期
关键词：
Prostate cancer; LNCaP; EGCG; PSA; Androgen receptor; TEA EPIGALLOCATECHIN GALLATE; GREEN TEA; ATHYMIC MICE; TUMOR-GROWTH; REGULATED ACTIVITY; CARCINOMA-CELLS; CYCLE ARREST; TRAMP MICE; INHIBITION; DEPRIVATION;
D O I：
10.1016/j.canlet.2008.10.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), inhibits the development and progression of prostate cancer in TRAMP mice and in men. We examined the effects of EGCG on LNCaP human prostate cancer sublines 104-S, 104-R1 and R1Ad representing different progression stages of prostate cancer. EGCG suppressed cell proliferation, prostate specific antigen (PSA) expression, and AR transcriptional activity in the different LNCaP sublines. Intraperitoneal administration of EGCG also suppressed the growth of relapsing R1Ad tumors and decreased tumor-derived serum PSA. Effects of EGCG on tumor PSA expression have the potential to affect accurate monitoring of patient tumor burden by serum PSA measurements. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：86 / 92
页数：7
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