Adiposity and Alzheimer's disease

被引:111
作者
Luchsinger, Jose A. [1 ,2 ,3 ,4 ]
Gustafsone, Deborah R. [5 ,6 ]
机构
[1] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10027 USA
[2] Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10027 USA
[3] Columbia Univ, Dept Med, Div Gen Med, Coll Phys & Surg, New York, NY 10027 USA
[4] Columbia Univ, Joseph P Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10027 USA
[5] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Sect Psychiat & Neurochem, Gothenburg, Sweden
[6] Med Coll Wisconsin, Dept Family & Community Med, Milwaukee, WI 53226 USA
关键词
adiposity; Alzheimer's disease; body weight; dementia; obese; overweight; BODY-MASS INDEX; WEIGHT-LOSS; FOLLOW-UP; WAIST CIRCUMFERENCE; RISK-FACTORS; INSULIN-RESISTANCE; INCIDENT DEMENTIA; BRAIN STRUCTURE; CENTRAL OBESITY; LEPTIN LEVELS;
D O I
10.1097/MCO.0b013e32831c8c71
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review Alzheimer's disease is the most common form of. dementia. There are no known preventive or curative measures. There is increasing evidence for the role of total adiposity, usually measured clinically as BMI, and central adiposity, in Alzheimer's disease. This topic is of enormous public health importance given the global epidemic of high adiposity and its consequences. Recent findings Salient publications in 2007 and 2008 showed that (a) central adiposity in middle age predicts dementia in old age; (b) the relation between high adiposity and dementia is attenuated with older age; (c) waist circumference in old age, a measure of central adiposity, may be a better predictor of dementia than BMI; (d) lower BMI predicts dementia in elderly people; and (e) weight loss may precede dementia diagnosis by decades, which may explain seemingly paradoxical findings. Summary The possibility that high adiposity increases Alzheimer's disease risk is alarming given global trends of overweight and obesity in the general population. However, prevention and manipulation of adiposity may also provide a means to prevent Alzheimer's disease. Treatment of weight loss in Alzheimer's disease may also be important but is beyond the score of this review.
引用
收藏
页码:15 / 21
页数:7
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