Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin

被引：0

作者：

Rodgers, Aoife M. ^{[1
]}

McCrudden, Maeliosa T. C. ^{[1
]}

Courtenay, Aaron J. ^{[1
]}

Kearney, Mary-Carmel ^{[1
]}

Edwards, Katherine L. ^{[2
]}

Ingram, Rebecca J. ^{[2
]}

Bengoechea, Jose ^{[2
]}

Donnelly, Ryan F. ^{[1
]}

机构：

[1] Queens Univ Belfast, Ctr Med Biol, Sch Pharm, Belfast, Antrim, North Ireland

[2] Queens Univ Belfast, Sch Med Dent & Biomed Sci, Wellcome Wolfson Inst Expt Med, Belfast, Antrim, North Ireland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 05期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

Klebsiella pneumoniae; gentamicin; microarray; transdermal delivery; MICRONEEDLE PATCHES; CARBAPENEM-RESISTANT; NEONATAL SEPSIS; VACCINATION; DELIVERY; ARRAYS;

D O I：

10.1128/AAC.02612-18

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Using a murine model of Klebsiella pneumoniae bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control K. pneumoniae infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts. This proof of concept study represents the first published data on the in vivo delivery of the antibiotic gentamicin via dissolving microarray patches, resulting in the control of bacterial infection.

引用

页数：5

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