The design of Ti6Al4V Primitive surface structure with symmetrical gradient of pore size in biomimetic bone scaffold

The living environment of bone cells isa complex curved one. And based on the modeling method of triply periodic minimal surfaces (TPMS) can be used to design a variety of complex surface structures, soit has been more and more widely studied and applied. In this paper, the main research object is the Primitive structure of TPMS. As an artificial bone scaffold structure, it must possess good mechanical properties, permeability, and is conducive to cell adhesion and proliferation. In this study, several groups of Ti6Al4V Primitive models are designed and fabricated by selective laser melting (SLM). The mechanical properties of scaffold are evaluated by mechanical compression test. The morphology of the scaffold model is characterized. The permeability of the scaffold was predicted and evaluated by computational fluid dynamics (CFD) analyses. Finally, the evaluation of the effects of Ti6A14V scaffold on cell growth is conducted by cytotoxicity test. The results show that the mechanical properties and permeability of the designed Primitive surface scaffold are pretty good as bone tissue replacement. Among them, the Psy scaffold with pore size and porosity varying along the axisymmetric gradient has significant research and application potential in the field of artificial bone scaffold. (c) 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).