Family specific rates of protein evolution

被引：18

作者：

Luz, H ^{[1
]}

Vingron, M ^{[1
]}

机构：

[1] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

来源：

BIOINFORMATICS | 2006年 / 22卷 / 10期

关键词：

D O I：

10.1093/bioinformatics/btl073

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework and spot sets of slow and fast evolving proteins. Results: We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.

引用

页码：1166 / 1171

页数：6

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