Preoperative 18F-FDG PET/CT in Pheochromocytomas and Paragangliomas Allows for Precision Surgery

被引：20
作者：
Nockel, Pavel [1 ]
El Lakis, Mustapha [1 ]
Gaitanidis, Apostolos [1 ]
Merkel, Roxanne [1 ]
Patel, Dhaval [1 ]
Nilubol, Naris [1 ]
Prodanov, Tamara [2 ]
Pacak, Karel [2 ]
Kebebew, Electron [1 ,3 ]
机构：
[1] NCI, Endocrine Oncol Branch, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA
[2] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Med Neuroendocrinol, NIH, Bethesda, MD USA
[3] George Washington Univ, Sch Med & Hlth Sci, Dept Surg, Washington, DC 20052 USA
来源：
ANNALS OF SURGERY | 2019年 / 269卷 / 04期
关键词：
18F-FDG PET/CT; adrenalectomy; imaging; paraganglioma; pheochromocytoma; METASTATIC PHEOCHROMOCYTOMA; GA-68-DOTATATE; LOCALIZATION; SUPERIORITY; SOCIETY;
D O I：
10.1097/SLA.0000000000002671
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background: Fluorodeoxyglucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT) imaging is recommended in patients with metastatic pheochromocytoma (PC) and paraganglioma (PGL). There are no data on whether routine preoperative F-18-FDG PET/CT in all patients with PC/PGL impacts surgical management. Objective: The aim of this study was to determine whether routine preoperative F-18-FDG PET/CT imaging affects the surgical management of patients with PC/PGLs. Methods: We analyzed clinical, biochemical, genetic, and anatomic imaging data in 93 consecutive patients with PC/PGL who collectively underwent a total of 100 operations and who had preoperative F-18-FDG PET/CT imaging. Results: Of 100 operations, preoperative F-18-FDG PET/CT showed additional lesions compared to anatomic imaging in 15 cases. These patients were more likely to undergo an open surgical approach (P < 0.05). Presence of genetic mutation, redo operations, sex, age, or tumor size had no significant association with finding additional lesions on F-18-FDG PET/CT. Conclusions: Additional lesions detected on preoperative F-18-FDG-PET/CT imaging have an impact on the surgical approach in patients with PC/PGLs. Therefore, surgeons should routinely obtain F-18-FDG-PET/CT imaging in patients with PC/PGL to allow for a more precise surgical intervention.
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收藏
页码：741 / 747
页数：7
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