HIV-1-induced depletion of CD4+ T cells in the gut:: mechanism and therapeutic implications

被引：20

作者：

Chase, A

Zhou, Y

Siliciano, RF

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] Howard Hughes Med Inst, Baltimore, MD 21205 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2006年 / 27卷 / 01期

关键词：

D O I：

10.1016/j.tips.2005.11.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mechanism of CD4(+) T-cell depletion remains a central unresolved issue in AIDS research. Recent studies have examined the massive depletion of CD4(+) T cells observed in macaque models of acute HIV infection. A key question is whether the observed CD4(+) T-cell death is due to direct consequences of viral infection and to indirect mechanisms including increased expression of mediators of T-cell apoptosis. The therapeutic implications of the early CD4(+) T-cell loss are discussed.

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页码：4 / 7

页数：4

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