Using Machine Learning to Identify Heterogeneous Effects in Randomized Clinical Trials-Moving Beyond the Forest Plot and Into the Forest

被引:10
作者
Goldstein, Benjamin A. [1 ]
Rigdon, Joseph [2 ]
机构
[1] Duke Univ, Sch Med, Dept Biostat & Bioinformat, 2424 Erwin Rd,Ste 9023, Durham, NC 27705 USA
[2] Stanford Univ, Sch Med, Quantitat Sci Unit, Palo Alto, CA 94304 USA
关键词
D O I
10.1001/jamanetworkopen.2019.0004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:3
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共 10 条
  • [1] Hydrological prediction in a non-stationary world
    Clarke, Robin T.
    [J]. HYDROLOGY AND EARTH SYSTEM SCIENCES, 2007, 11 (01) : 408 - 414
  • [2] TESTING FOR QUALITATIVE INTERACTIONS BETWEEN TREATMENT EFFECTS AND PATIENT SUBSETS
    GAIL, M
    SIMON, R
    [J]. BIOMETRICS, 1985, 41 (02) : 361 - 372
  • [3] Goldstein BA, OUTCOME MODEL APPROA
  • [4] Subject Matter Knowledge in the Age of Big Data and Machine Learning
    Goldstein, Benjamin A.
    Carlson, David
    Bhavsar, Nrupen A.
    [J]. JAMA NETWORK OPEN, 2018, 1 (04)
  • [5] Personalized evidence based medicine: predictive approaches to heterogeneous treatment effects
    Kent, David M.
    Steyerberg, Ewout
    van Klaveren, David
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2018, 363
  • [6] Estimating Individual Treatment Effect in Observational Data Using Random Forest Methods
    Lu, Min
    Sadiq, Saad
    Feaster, Daniel J.
    Ishwaran, Hemant
    [J]. JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS, 2018, 27 (01) : 209 - 219
  • [7] Preventing false discovery of heterogeneous treatment effect subgroups in randomized trials
    Rigdon, Joseph
    Baiocchi, Michael
    Basu, Sanjay
    [J]. TRIALS, 2018, 19
  • [8] Assessment of Risk of Harm Associated With Intensive Blood Pressure Management Among Patients With Hypertension Who Smoke A Secondary Analysis of the Systolic Blood Pressure Intervention Trial
    Scarpa, Joseph
    Bruzelius, Emilie
    Doupe, Patrick
    Le, Matthew
    Faghmous, James
    Baum, Aaron
    [J]. JAMA NETWORK OPEN, 2019, 2 (03)
  • [9] A Randomized Trial of Intensive versus Standard Blood-Pressure Control
    Wright, Jackson T., Jr.
    Williamson, Jeff D.
    Whelton, Paul K.
    Snyder, Joni K.
    Sink, Kaycee M.
    Rocco, Michael V.
    Reboussin, David M.
    Rahman, Mahboob
    Oparil, Suzanne
    Lewis, Cora E.
    Kimmel, Paul L.
    Johnson, Karen C.
    Goff, David C., Jr.
    Fine, Lawrence J.
    Cutler, Jeffrey A.
    Cushman, William C.
    Cheung, Alfred K.
    Ambrosius, Walter T.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (22) : 2103 - 2116
  • [10] 2011, CIRCULATION, V124, P544, DOI DOI 10.1161/CIRCULATIONAHA.111.047498