Effect of Tilia cordata flower on lymphocyte proliferation:: participation of peripheral type benzodiazepine binding sites

被引：10

作者：

Anesini, C

Werner, S

Borda, E

机构：

[1] Univ Buenos Aires, Fac Odontol, Catedra Farmacol, RA-1414 Buenos Aires, DF, Argentina

[2] Consejo Nacl Invest Cient & Tecn, CEFYBO, RA-1414 Buenos Aires, DF, Argentina

来源：

FITOTERAPIA | 1999年 / 70卷 / 04期

关键词：

Tilia cordata; lymphocyte proliferation; peripheral benzodiazepine receptors;

D O I：

10.1016/S0367-326X(99)00049-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aqueous extract of Tilia cordata flowers showed in vitro stimulatory effects on lymphocyte proliferation (maximum stimulatory concentration: 20 mu g/ml). This effect was mimicked by Ro 5-4864, an agonist of the peripheral benzodiazepine receptor, and by Pk 11195, an agonist/antagonist of the same receptor. These results suggest that Tilia extract could exert its stimulatory effect acting as an agonist of the peripheral benzodiazepine receptor. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：361 / 367

页数：7

共 17 条

[1] CHARACTERIZATION OF PERIPHERAL-TYPE BENZODIAZEPINE BINDING-SITES ON HUMAN-LYMPHOCYTES AND LYMPHOMA CELL-LINES AND THEIR ROLE IN CELL-GROWTH [J].