Characterization of in vitro activity and predictive biomarkers of the novel p21-activated kinase 4 (PAK4) inhibitor, PF-3758309, in colorectal cancer cell lines

被引:0
|
作者
Kulikowski, Gillian N.
Pitts, Todd M.
Tan, Aik Choon
Tentler, John J.
Britt, Blair C.
Britt, Byron W.
Murray, Brion W.
Carley, William
Smeal, Tod
Guo, Chuangxing
Eckhardt, S. Gail
机构
关键词
D O I
10.1158/1535-7163.TARG-09-B169
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B169
引用
收藏
页数:3
相关论文
共 50 条
  • [21] PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings
    Byung Jun Ryu
    Hyuk Lee
    Seong-Ho Kim
    Jung-Nyoung Heo
    Sik-Won Choi
    Jeong-Tae Yeon
    Jeongmin Lee
    Jongsung Lee
    Jae Youl Cho
    Seong Hwan Kim
    Sang Yeol Lee
    Molecular and Cellular Biochemistry, 2014, 389 : 69 - 77
  • [22] Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma
    Aboukameel, Amro
    Muqbil, Irfana
    Senapedis, William
    Baloglu, Erkan
    Landesman, Yosef
    Shacham, Sharon
    Kauffman, Michael
    Philip, Philip A.
    Mohammad, Ramzi M.
    Azmi, Asfar S.
    MOLECULAR CANCER THERAPEUTICS, 2017, 16 (01) : 76 - 87
  • [23] PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings
    Ryu, Byung Jun
    Lee, Hyuk
    Kim, Seong-Ho
    Heo, Jung-Nyoung
    Choi, Sik-Won
    Yeon, Jeong-Tae
    Lee, Jeongmin
    Lee, Jongsung
    Cho, Jae Youl
    Kim, Seong Hwan
    Lee, Sang Yeol
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2014, 389 (1-2) : 69 - 77
  • [24] Depletion of p21-activated kinase 4, PAK4, inhibits cellular proliferation, motility and clonogenicity in oral squamous cell carcinoma
    Chung, Felicia F.
    Tan, Si-Hoey
    Raja, Vijay J.
    Ng, Pei Yuen
    Paterson, Ian C.
    Tan, Chye Ling
    Leong, Chee-Onn
    CANCER RESEARCH, 2017, 77
  • [25] Author Correction: Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)
    Byung Hak Ha
    Sezin Yigit
    Nalini Natarajan
    Elizabeth M. Morse
    David A. Calderwood
    Titus J. Boggon
    Communications Biology, 6
  • [26] P21-ACTIVATED KINASE 4 (PAK4) REGULATES MULTIPLE MYELOMA (MM) CELL GROWTH AND SURVIVAL BY MODULATION OF CRITICAL TRANSCRIPTIONAL PATHWAYS: THERAPEUTIC APPLICATION OF PAK4 ALLOSTERIC INHIBITORS
    Fulciniti, M. T.
    Oliva, S.
    Amodio, N.
    Roccaro, A.
    Bandi, R. L.
    Daisy, H.
    Cagnetta, A.
    Senapedis, W.
    Baloglu, E.
    Anderson, K. C.
    Ghobrial, I.
    Munshi, N. C.
    HAEMATOLOGICA, 2015, 100 : 78 - 79
  • [27] Design, synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated kinase 4 (PAK4) inhibitors
    Song, Shuai
    Li, Xiaodong
    Guo, Jing
    Hao, Chenzhou
    Feng, Yan
    Guo, Bingyu
    Liu, Tongchao
    Zhang, Qiaoling
    Zhang, Zhen
    Li, Ruijuan
    Wang, Jian
    Lin, Bin
    Li, Feng
    Zhao, Dongmei
    Cheng, Maosheng
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 13 (12) : 3803 - 3818
  • [28] p-21 activated kinase 4 (PAK4) role in pancreatic cancer stem cells
    Herreros-Villanueva, Marta
    Bujanda, Luis
    TRANSLATIONAL CANCER RESEARCH, 2016, 5 : S335 - S337
  • [29] Loss of p21-activated kinase Mbt/PAK4 causes Parkinson-like phenotypes in Drosophila
    Puetz, Stephanie M.
    Kram, Jette
    Rauh, Elisa
    Kaiser, Sophie
    Toews, Romy
    Lueningschroer-Wang, Yi
    Rieger, Dirk
    Raabe, Thomas
    DISEASE MODELS & MECHANISMS, 2021, 14 (06)
  • [30] INHIBITION OF P21-ACTIVATED KINASE 4 (PAK4) REVERTS IMMUNE EXCLUSION AND RESTORES ANTITUMOR IMMUNITY IN THE TUMOR MICROENVIRONMENT
    Zhou, Yu 'Jerry'
    Chu, Gina
    Hendrickson, Eleanore
    Gullo-Brown, Johnni
    Chavez, Brandy
    McAlpine, Indrawan
    Rui, Eugene
    Doran, Shawn
    Timofeevski, Sergei
    Heyen, Jonathan
    Kinong, Jennifer
    Tang, Szu-Yu
    Oyer, Jon
    Rayannavar, Vinayak
    Nager, Andrew
    Ching, Keith
    Shi, Stephanie
    Bhadra, Rajarshi
    Dillon, Christopher
    Gururajan, Murali
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A768 - A768