Aspergillus felis sp nov., an Emerging Agent of Invasive Aspergillosis in Humans, Cats, and Dogs

被引：80

作者：

Barrs, Vanessa R. ^{[1
]}

van Doorn, Tineke M. ^{[2
]}

Houbraken, Jos ^{[2
]}

Kidd, Sarah E. ^{[3
]}

Martin, Patricia ^{[1
]}

Pinheiro, Maria Dolores ^{[4
]}

Richardson, Malcolm ^{[5
,6
]}

Varga, Janos ^{[7
]}

Samson, Robert A. ^{[2
]}

机构：

[1] Univ Sydney, Fac Vet Sci, Sydney, NSW 2006, Australia

[2] Cent Bur Schimmelcultures Koninklijke Nederlandse, Dept Appl & Ind Mycol, Utrecht, Netherlands

[3] Womens & Childrens Hosp, Mycol Unit, SA Pathol, Adelaide, SA, Australia

[4] Hosp Sao Joao, Microbiol Lab, Serv Clin Pathol, Oporto, Portugal

[5] Univ S Manchester Hosp, Educ & Res Ctr, Mycol Reference Ctr Manchester, Manchester M20 8LR, Lancs, England

[6] Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[7] Univ Szeged, Fac Sci, Dept Microbiol, Szeged, Hungary

来源：

PLOS ONE | 2013年 / 8卷 / 06期

关键词：

EPIDEMIOLOGIC CUTOFF VALUES; SPECIES RECOGNITION; POLYPHASIC TAXONOMY; MIC DISTRIBUTIONS; SECTION FUMIGATI; INFECTIONS; UDAGAWAE; LENTULUS; PATIENT;

D O I：

10.1371/journal.pone.0064871

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We describe a novel heterothallic species in Aspergillus section Fumigati, namely A. felis (neosartorya-morph) isolated from three host species with invasive aspergillosis including a human patient with chronic invasive pulmonary aspergillosis, domestic cats with invasive fungal rhinosinusitis and a dog with disseminated invasive aspergillosis. Disease in all host species was often refractory to aggressive antifungal therapeutic regimens. Four other human isolates previously reported as A. viridinutans were identified as A. felis on comparative sequence analysis of the partial beta-tubulin and/or calmodulin genes. A. felis is a heterothallic mold with a fully functioning reproductive cycle, as confirmed by mating-type analysis, induction of teleomorphs within 7 to 10 days in vitro and ascospore germination. Phenotypic analyses show that A. felis can be distinguished from the related species A. viridinutans by its ability to grow at 45 degrees C and from A. fumigatus by its inability to grow at 50 degrees C. Itraconazole and voriconazole cross-resistance was common in vitro.

引用

页数：11

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