von Willebrand factor and cancer: A renewed interest

被引：78

作者：

Franchini, Massimo ^{[1
]}

Frattini, Francesco ^{[1
]}

Crestani, Silvia ^{[1
]}

Bonfanti, Carlo ^{[1
]}

Lippi, Giuseppe ^{[2
]}

机构：

[1] Carlo Poma Hosp, Dept Transfus Med & Hematol, Mantua, Italy

[2] Azienda Osped Univ Parma, UO Diagnost Ematochim, Dipartimento Patol & Med Lab, Parma, Italy

来源：

THROMBOSIS RESEARCH | 2013年 / 131卷 / 04期

关键词：

von Willebrand factor; von Willebrand disease; cancer; angiogenesis; metastasis; ENDOTHELIAL-CELLS; METASTASIS; DISEASE; CARCINOMA; ANGIOGENESIS; PLASMA; MICE; COAGULATION; HEMOPHILIA; DISORDERS;

D O I：

10.1016/j.thromres.2013.01.015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Von Willebrand factor (VWF), the largest human plasma protein, is an adhesive multimeric glycoprotein that mediates platelet adhesion to both the subendothelial matrix and endothelial surfaces and acts as a carrier for coagulation factor VIII in the circulation. Besides its essential role in hemostasis, there is growing evidence from the literature that VWF has an additional antitumor effect, mainly by exerting negative modulation on angiogenesis and apoptosis. Current knowledge on the link between VWF and cancer is summarized in this review, based on an analysis of the most important experimental and clinical studies. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：290 / 292

页数：3

共 36 条

[1]

Bercaw Jennifer L, 2010, J Pediatr Adolesc Gynecol, V23, pe111, DOI 10.1016/j.jpag.2009.09.006

[2] Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders [J].

Bruggemann, Lois W. ;

Versteeg, Henri H. ;

Niers, Tatjana M. ;

Reitsma, Pieter H. ;

Spek, C. Arnold .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2008, 12 (6B) :2622-2627

[3]

Castaman G, 2003, HAEMATOLOGICA, V88, P94

[4]

FLOYD CM, 1992, J LAB CLIN MED, V119, P467

[5] The role of von Willebrand factor in hemorrhagic and thrombotic disorders [J].

Franchini, Massimo ;

Lippi, Giuseppe .

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2007, 44 (02) :115-149

[6] Haemophilia and cancer: a personal perspective [J].

Franchini, Massimo .

BLOOD TRANSFUSION, 2013, 11 (01) :26-31

[7] Thrombin and Cancer: From Molecular Basis to Therapeutic Implications [J].

Franchini, Massimo ;

Mannucci, Pier Mannuccio .

SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2012, 38 (01) :95-101

[8] Hemophilia and cancer: A new challenge for hemophilia centers [J].

Franchini, Massimo ;

Lippi, Giuseppe ;

Montagnana, Martina ;

Targher, Giovanni ;

Zaffanello, Marco ;

Salvagno, Gian Luca ;

Rivolta, Gianna Franca ;

Di Perna, Caterina ;

Tagliaferri, Annarita .

CANCER TREATMENT REVIEWS, 2009, 35 (04) :374-377

[9] Von Willebrand Factor: Another Janus-Faced Hemostasis Protein [J].

Franchini, Massimo ;

Mannucci, Pier Mannuccio .

SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2008, 34 (07) :663-669

[10] PRETREATMENT PLASMA-LEVELS OF FIBRINOPEPTIDE-A (FPA), D-DIMER (DD), AND VON-WILLEBRAND-FACTOR (VWF) IN PATIENTS WITH OVARIAN-CARCINOMA [J].

GADDUCCI, A ;

BAICCHI, U ;

MARRAI, R ;

DELBRAVO, B ;

FOSELLA, PV ;

FACCHINI, V .

GYNECOLOGIC ONCOLOGY, 1994, 53 (03) :352-356

← 1 2 3 4 →