von Willebrand factor and cancer: A renewed interest

被引：78
作者：
Franchini, Massimo [1 ]
Frattini, Francesco [1 ]
Crestani, Silvia [1 ]
Bonfanti, Carlo [1 ]
Lippi, Giuseppe [2 ]
机构：
[1] Carlo Poma Hosp, Dept Transfus Med & Hematol, Mantua, Italy
[2] Azienda Osped Univ Parma, UO Diagnost Ematochim, Dipartimento Patol & Med Lab, Parma, Italy
来源：
THROMBOSIS RESEARCH | 2013年 / 131卷 / 04期
关键词：
von Willebrand factor; von Willebrand disease; cancer; angiogenesis; metastasis; ENDOTHELIAL-CELLS; METASTASIS; DISEASE; CARCINOMA; ANGIOGENESIS; PLASMA; MICE; COAGULATION; HEMOPHILIA; DISORDERS;
D O I：
10.1016/j.thromres.2013.01.015
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Von Willebrand factor (VWF), the largest human plasma protein, is an adhesive multimeric glycoprotein that mediates platelet adhesion to both the subendothelial matrix and endothelial surfaces and acts as a carrier for coagulation factor VIII in the circulation. Besides its essential role in hemostasis, there is growing evidence from the literature that VWF has an additional antitumor effect, mainly by exerting negative modulation on angiogenesis and apoptosis. Current knowledge on the link between VWF and cancer is summarized in this review, based on an analysis of the most important experimental and clinical studies. (C) 2013 Elsevier Ltd. All rights reserved.
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收藏
页码：290 / 292
页数：3
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