Study of hydrodynamic size distribution and hyperthermia temperature of chitosan encapsulated zinc-substituted manganese nano ferrites suspension

Hyperthermia opens a safe alternative for cancer treatment. Researchers synthesize new materials that can be successfully used for the biomedical application. We have synthesized Mn1-xZnxFe2O4 (0.2 <= x <= 1.0, in the steps of 0.2) and coated the samples with chitosan. The structural properties of the nanoparticles were determined by XRD and TEM analysis. Face-centered cubic structure of the nano ferrites has been revealed by XRD analysis. It has been found that both the theoretical and experimental lattice constant decreases with the addition of zinc. The range of theoretical and experimental lattice constants is 8.336 angstrom to 8.275 angstrom and 8.460 angstrom to 8.399 angstrom, respectively. EDS studies revealed the elemental distribution of both bare and coated ferrite nanoparticles. VSM has characterized the field dependent magnetization. Mossbauer spectroscopy revealed that all samples exhibit superparamagnetic behavior except Mn0.8Zn0.2Fe2O4. The shift of iron ion in the octahedral site from the tetrahedral site was observed with the addition of zinc. The maximum hydrodynamic diameter of the coated samples was found around 220 nm which is suitable for the biomedical application. The maximum hyperthermia temperature of the coated samples has been estimated.