Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes

被引：21

作者：

Mailloux, Adam W. ^{[1
]}

Epling-Burnette, Pearlie K. ^{[1
,2
]}

机构：

[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Program Immunol, Tampa, FL 33612 USA

[2] James A Haley VA Hosp, Tampa, FL USA

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 02期

关键词：

regulatory T cells; myelodysplastic syndrome; immunoediting; immune escape; leukemia;

D O I：

10.4161/onci.22654

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myleodysplastic syndromes (MDS) are pre-malignant hematopoietic diseases that can progress to acute myeloid leukemia (AML) progression in conjunction with changes in immune function. In this model of leukemia evolution, the expansion of immunosuppressive regulatory T cells (Tregs) contributes to immune escape. Here, we discuss the importance of Treg-memory phenotype switching as a poor prognostic indicator in MDS.

引用

页数：3

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