Lignans from Opuntia ficus-indica seeds protect rat primary hepatocytes and HepG2 cells against ethanol-induced oxidative stress

被引：17
|
作者：
Kim, Jung Wha [1 ,2 ]
Yang, Heejung [3 ]
Kim, Hyeon Woo [1 ,2 ]
Kim, Hong Pyo [4 ]
Sung, Sang Hyun [1 ,2 ]
机构：
[1] Seoul Natl Univ, Coll Pharm, Seoul, South Korea
[2] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul, South Korea
[3] Kangwon Natl Univ, Coll Pharm, Chunchon, South Korea
[4] Ajou Univ, Coll Pharm, Suwon, South Korea
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2017年 / 81卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
Opuntia ficus-indica; lignin; hepatoprotective activity; heme oxygenase-1; VAR; SABOTEN; FRUIT JUICE; MORINDA-CITRIFOLIA; CONSTITUENTS; ANTIOXIDANT;
D O I：
10.1080/09168451.2016.1234930
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bioactivity-guided isolation of Opuntia ficus-indica (Cactaceae) seeds against ethanol-treated primary rat hepatocytes yielded six lignan compounds. Among the isolates, furofuran lignans 4-6, significantly protected rat hepatocytes against ethanol-induced oxidative stress by reducing intracellular reactive oxygen species levels, preserving antioxidative defense enzyme activities, and maintaining the glutathione content. Moreover, 4 dose-dependently induced the heme oxygenase-1 expression in HepG2 cells.
引用
收藏
页码：181 / 183
页数：3
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