High Serum Levels of High-Mobility Group Box 1 (HMGB1) and Low Levels of Heat Shock Protein 70 (Hsp70) are Associated with Poor Prognosis in Patients with Acute Pancreatitis

被引：26

作者：

Arriaga-Pizano, Lourdes ^{[1
]}

Bosco-Garate, Ilka ^{[1
]}

Luis Martinez-Ordaz, Jose ^{[2
]}

Wong-Baeza, Isabel ^{[3
]}

Gutierrez-Mendoza, Mireille ^{[1
]}

Sanchez-Fernandez, Patricio ^{[2
]}

Lopez-Macias, Constantino ^{[1
]}

Isibasi, Armando ^{[1
]}

Pelaez-Luna, Mario ^{[4
]}

Cerbulo-Vazquez, Arturo ^{[5
]}

Torres-Gonzalez, Ruben ^{[6
]}

Ferat-Osorio, Eduardo ^{[1
,2
]}

机构：

[1] Inst Mexicano Seguro Social, Hosp Especialidades, Ctr Med Nacl Siglo XXI, Unidad Invest Med Inmunoquim,Unidad Med Alta Espe, Ciudad De Mexico, Mexico

[2] Inst Mexicano Seguro Social, Hosp Especialidades, Ctr Med Nacl Siglo XXI, Serv Cirugia Gastrointestinal,Unidad Med Alta Esp, Ciudad De Mexico, Mexico

[3] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Inmunol, Ciudad De Mexico, Mexico

[4] Univ Nacl Autonoma Mexico, Fac Med, Dept Med Expt, Lab Higado Pancreas & Motilidad Intestinal, Ciudad De Mexico, Mexico

[5] Univ Nacl Autonoma Mexico, Fac Med, Programa Estudios Combinados Med, Ciudad De Mexico, Mexico

[6] Inst Mexicano Seguro Social, Hosp Traumatol & Ortopedia, Direcc Educ & Invest Salud, Ciudad De Mexico, Mexico

来源：

ARCHIVES OF MEDICAL RESEARCH | 2018年 / 49卷 / 07期

关键词：

HMGB1; Hsp70; Acude pancreatitis; Cytokines; HEAT-SHOCK PROTEINS; ENDOGENOUS LIGANDS; INJURY; INTERLEUKIN-6; INFLAMMATION; ACTIVATION; PROTECTION; RECEPTOR; RELEASE; SEPSIS;

D O I：

10.1016/j.arcmed.2019.02.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Introduction. Cell damage in Acute Pancreatitis (AP) lead to release of cytokines and HMGB1 and Hsp70. While Hsp70 plays a role in cytoprotection, when released to extra cellular milieu constitutes, as HMGB1, a danger signal and trigger pro-inflammatory responses. These molecules seem to be related to the clinical progression; but because no evidence exists about them as molecular network in AP development, we quantify HSP70, HMGB1, and cytokines in patients with AP and search for correlations with severity and prognosis. Methods. Fifteen patients with AP were included. The average age was 52 years. Six patients had mild pancreatitis, 4 were moderately severe and 5 with a severe form. Blood samples were taken within the first 24 h, at 3d and 7d from the start. Serum HMGB1 and Hsp70 were determined using ELISA; TNF-alpha, IL-1 beta, IL-6, IL-8, IL-10 and IL-12p70 were determined by bead based immuassay. Results. Of all 15 patients recruited, 4 were women. Eight patients had APACHEII score higher than 8. Two patients died from AP related complications. Increase in serum HMGB1 and decrease of Hsp70 were associated with the severity and mortality. TNF-alpha, IL-6 and IL-8 were higher in patients that did not survive, in those with an APACHE II >8, and in those with severe AP. Conclusions. High HMGB1 and low Hsp70 were associated with poor prognosis. Hsp70 might play a protective role in AP. TNF-alpha, IL-6, IL-8, HMGB1 and Hsp70 during hospital admissions might serve to evaluate risk of death due to AP. Published by Elsevier Inc. on behalf of IMSS.

引用

页码：504 / 511

页数：8

共 48 条

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