Functionalized GO Nanovehicles with Nitric Oxide Release and Photothermal Activity-Based Hydrogels for Bacteria-Infected Wound Healing

被引：218
作者：
Huang, Shaoshan [1 ]
Liu, Huiling [1 ]
Liao, Kedan [3 ]
Hu, Qinqin [3 ]
Guo, Rui [1 ,2 ]
Deng, Kaixian [3 ]
机构：
[1] Jinan Univ, Guangdong Prov Engn & Technol Res Ctr Drug Carrie, Key Lab Biomat, Guangdong Higher Educ Inst,Dept Biomed Engn, Guangzhou 510632, Peoples R China
[2] Jinan Univ, Dept Biomed Engn, Guangzhou 510632, Peoples R China
[3] Southern Med Univ, Shunde Hosp, Peoples Hosp Shunde 1, Foshan 528308, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2020年 / 12卷 / 26期
关键词：
hydrogel; BNN6; nitric oxide; gas therapy; wound healing; BETA-CYCLODEXTRIN; NANOPARTICLES; GRAPHENE; CANCER; ANTIBIOTICS; GENERATION; DELIVERY;
D O I：
10.1021/acsami.0c04080
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Bacteria-infected wounds are attracting increasing attention, as antibiotic misuse and multidrug-resistant bacteria complicate their treatment. Herein, we reported a photothermal activity-based drug consisting of beta-cyclodextrin (beta CD)-functionalized graphene oxide (GO) near-infrared light-responsive nanovehicles combined with the nitric oxide donor BNN6, in a methacrylate-modified gelatin (GelMA)/hyaluronic acid graft dopamine (HA-DA) hydrogel. The synergistic effects of photothermal and gas therapies are expected to improve antibacterial efficiency and reduce drug resistance. The results revealed that GelMA/HA-DA/GO-beta CD-BNN6 was an ideal antibacterial material that improved collagen deposition and angiogenesis and promoted wound healing in a mouse model of full-thickness skin repair, compared to the commercially available Aquacel Ag dressing. We developed a multifunctional nanocomposite hydrogel that exhibited antibacterial and angiogenic properties, adhesiveness, and mechanical properties that enhance the regeneration of bacteria-infected wounds.
引用
收藏
页码：28952 / 28964
页数：13
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