HCN channels Function and clinical implications

被引:168
作者
Benarroch, Eduardo E. [1 ]
机构
[1] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA
关键词
ACTIVATED CATION CHANNELS; CURRENT I-H; ABSENCE EPILEPSY; PYRAMIDAL NEURONS; ION CHANNELS; MICE LACKING; EXCITABILITY; INTEGRATION; CHANNELOPATHIES; PATHOPHYSIOLOGY;
D O I
10.1212/WNL.0b013e31827dec42
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
[No abstract available]
引用
收藏
页码:304 / 310
页数:7
相关论文
共 38 条
[1]   Compartmental distribution of hyperpolarization-activated cyclic-nucleotide-gated channel 2 and hyerpolarization-activated cyclic-nucleotide-gated channel 4 in thalamic reticular and thalamocortical relay neurons [J].
Abbas, S. Y. ;
Ying, S. W. ;
Goldstein, P. A. .
NEUROSCIENCE, 2006, 141 (04) :1811-1825
[2]   Selective Participation of Somatodendritic HCN Channels in Inhibitory But Not Excitatory Synaptic Integration in Neurons of the Subthalamic Nucleus [J].
Atherton, Jeremy F. ;
Kitano, Katsunori ;
Baufreton, Jerome ;
Fan, Kai ;
Wokosin, David ;
Tkatch, Tatiana ;
Shigemoto, Ryuichi ;
Surmeier, D. James ;
Bevan, Mark D. .
JOURNAL OF NEUROSCIENCE, 2010, 30 (47) :16025-16040
[3]   HCN-related channelopathies [J].
Baruscotti, Mirko ;
Bottelli, Georgia ;
Milanesi, Raffaella ;
DiFrancesco, Jacopo C. ;
DiFrancesco, Dario .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2010, 460 (02) :405-415
[4]   Hyperpolarization-activated current Ih disconnects somatic and dendritic spike initiation zones in layer V pyramidal neurons [J].
Berger, T ;
Senn, W ;
Lüscher, HR .
JOURNAL OF NEUROPHYSIOLOGY, 2003, 90 (04) :2428-2437
[5]   Hyperpolarization-Activated Cation Channels: From Genes to Function [J].
Biel, Martin ;
Wahl-Schott, Christian ;
Michalakis, Stylianos ;
Zong, Xiangang .
PHYSIOLOGICAL REVIEWS, 2009, 89 (03) :847-885
[6]   Impaired regulation of thalamic pacemaker channels through an imbalance of subunit expression in absence epilepsy [J].
Budde, T ;
Caputi, L ;
Kanyshkova, T ;
Staak, R ;
Abrahamczik, C ;
Munsch, T ;
Pape, HC .
JOURNAL OF NEUROSCIENCE, 2005, 25 (43) :9871-9882
[7]   Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2 [J].
Chung, Wendy K. ;
Shin, Minyoung ;
Jaralmillo, Thomas C. ;
Leibel, Rudolph L. ;
LeDuc, Charles A. ;
Fischer, Stuart G. ;
Tzilianos, Efthia ;
Gheith, Ayman A. ;
Lewis, Alan S. ;
Chetkovich, Dane M. .
NEUROBIOLOGY OF DISEASE, 2009, 33 (03) :499-508
[8]   Augmented Currents of an HCN2 Variant in Patients with Febrile Seizure Syndromes [J].
Dibbens, Leanne M. ;
Reid, Christopher A. ;
Hodgson, Bree ;
Thomas, Evan A. ;
Phillips, Alison M. ;
Gazina, Elena ;
Cromer, Brett A. ;
Clarke, Alison L. ;
Baram, Tallie Z. ;
Scheffer, Ingrid E. ;
Berkovic, Samuel F. ;
Petrou, Steven .
ANNALS OF NEUROLOGY, 2010, 67 (04) :542-546
[9]   Recessive Loss-of-Function Mutation in the Pacemaker HCN2 Channel Causing Increased Neuronal Excitability in a Patient with Idiopathic Generalized Epilepsy [J].
DiFrancesco, Jacopo C. ;
Barbuti, Andrea ;
Milanesi, Raffaella ;
Coco, Stefania ;
Bucchi, Annalisa ;
Bottelli, Georgia ;
Ferrarese, Carlo ;
Franceschetti, Silvana ;
Terragni, Benedetta ;
Baruscotti, Mirko ;
DiFrancesco, Dario .
JOURNAL OF NEUROSCIENCE, 2011, 31 (48) :17327-17337
[10]   HCN2 ion channels: an emerging role as the pacemakers of pain [J].
Emery, Edward C. ;
Young, Gareth T. ;
McNaughton, Peter A. .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2012, 33 (08) :456-463