Carry-Over of Aflatoxin B1 to Aflatoxin M1 in High Yielding Israeli Cows in Mid- and Late-Lactation

被引:91
作者
Britzi, Malka [1 ]
Friedman, Shmulik [2 ]
Miron, Joshua [3 ]
Solomon, Ran [4 ]
Cuneah, Olga [5 ]
Shimshoni, Jakob A. [5 ]
Soback, Stefan [1 ]
Ashkenazi, Rina [6 ]
Armer, Sima [6 ]
Shlosberg, Alan [5 ]
机构
[1] Kimron Vet Inst, Natl Residue Control Lab, IL-50250 Bet Dagan, Israel
[2] Israeli Dairy Board, IL-56470 Yehud, Israel
[3] Agr Res Org, Dept Ruminant Sci, IL-50250 Bet Dagan, Israel
[4] Ambar Feed Prod Co, IL-38810 Gan Shmuel, Israel
[5] Kimron Vet Inst, Dept Toxicol, IL-50250 Bet Dagan, Israel
[6] Plant Protect & Inspect Serv, Dept Chem, IL-50250 Bet Dagan, Israel
关键词
aflatoxin B1; aflatoxin M1; carry-over; Israeli-Holstein cows; DAIRY-COWS; MILK; FEED; METABOLISM; MYCOTOXINS; FOOD;
D O I
10.3390/toxins5010173
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
The potent hepatotoxin and carcinogen aflatoxin B1 (AFB1) is a common mycotoxin contaminant of grains used in animal feeds. Aflatoxin M1 (AFM1) is the major metabolite of AFB1 in mammals, being partially excreted into milk, and is a possible human carcinogen. The maximum permitted concentration of AFM1 in cows' milk is 0.05 mu g/kg in Israel and the European Union. Since milk yield and the carry-over of AFB1 in the feed to AFM1 in the milk are highly correlated, it was considered important to determine the AFM1 carry-over in Israeli-Holstein dairy cows, distinguished by world record high milk production. Twelve such cows were used to determine AFM1 carry-over following daily oral administration of feed containing similar to 86 mu g AFB1 for 7 days. The mean carry-over rate at steady-state (Days 3-7) was 5.8% and 2.5% in mid-lactation and late-lactation groups, respectively. The carry-over appears to increase exponentially with milk yield and could be described by the equation: carry-over% = 0.5154 e(0.0521 x milk yield), with r(2) = 0.6224. If these data truly reflect the carry-over in the national Israeli dairy herd, the maximum level of AFB1 in feed should not exceed 1.4 mu g/kg, a value 3.6 times lower than the maximum residue level currently applied in Israel.
引用
收藏
页码:173 / 183
页数:11
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