African swine fever: A re-emerging viral disease threatening the global pig industry

被引:321
作者
Sanchez-Cordon, P. J. [1 ,2 ]
Montoya, M. [1 ]
Reis, A. L. [1 ]
Dixon, L. K. [1 ]
机构
[1] Pirbright Inst, Woking GU24 0NF, Surrey, England
[2] Anim & Plant Hlth Agcy APHA Weybridge, Addlestone KT15 3NB, Surrey, England
基金
英国生物技术与生命科学研究理事会;
关键词
African swine fever; Control; Epidemiology; Immune responses; Pathogenesis; Vaccination; DOMESTIC PIGS; RUSSIAN-FEDERATION; T-LYMPHOCYTES; INTRAMUSCULAR INOCULATION; TRANSMISSION ROUTES; ANTIBODY-RESPONSE; FARMING SYSTEMS; VIRUS ISOLATE; CYTOTOXIC-T; PROTECTION;
D O I
10.1016/j.tvjl.2017.12.025
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
African swine fever (ASF) recently has spread beyond sub-Saharan Africa to the Trans-Caucasus region, parts of the Russian Federation and Eastern Europe, In this new epidemiological scenario, the disease has similarities, but also important differences, compared to the situation in Africa, including the substantial involvement of wild boar. A better understanding of this new situation will enable better control and prevent further spread of disease. In this article, these different scenarios are compared, and recent information on the pathogenesis of ASF virus strains, the immune response to infection and prospects for developing vaccines is presented. Knowledge gaps and the prospects for future control are discussed. (C) 2018 The Pirbright Institute. Published by Elsevier Ltd.
引用
收藏
页码:41 / 48
页数:8
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