Dedifferentiation, Transdifferentiation, and Reprogramming: Future Directions in Regenerative Medicine

被引：63

作者：

Eguizabal, Cristina ^{[1
]}

Montserrat, Nuria ^{[1
]}

Veiga, Anna ^{[1
,2
]}

Belmonte, Juan Carlos Izpisua ^{[1
,3
]}

机构：

[1] Inst Univ Dexeus, Ctr Regenerat Med Barcelona, Barcelona, Spain

[2] Inst Univ Dexeus, Reprod Med Serv, Barcelona, Spain

[3] Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 93027 USA

来源：

SEMINARS IN REPRODUCTIVE MEDICINE | 2013年 / 31卷 / 01期

关键词：

regenerative medicine; stem cells; dedifferentiation; transdifferentiation; reprogramming; PLURIPOTENT STEM-CELLS; ZEBRAFISH HEART REGENERATION; PRIMORDIAL GERM-CELLS; NUCLEAR TRANSFER; X-CHROMOSOME; CLONING EFFICIENCY; HISTONE VARIANTS; DNA METHYLATION; GENE-EXPRESSION; SOMATIC-CELLS;

D O I：

10.1055/s-0032-1331802

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The main goal of regenerative medicine is to replace damaged tissue. To do this it is necessary to understand in detail the whole regeneration process including differentiated cells that can be converted into progenitor cells (dedifferentiation), cells that can switch into another cell type (transdifferentiation), and somatic cells that can be induced to become pluripotent cells (reprogramming). By studying the regenerative processes in both nonmammal and mammal models, natural or artificial processes could underscore the molecular and cellular mechanisms behind these phenomena and be used to create future regenerative strategies for humans.

引用

页码：82 / 94

页数：13

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